Effects of dose loading conditions and device geometry on the transport and aerosolization in dry powder inhalers: A simulation study.
Effects of dose loading conditions and device geometry on the transport and aerosolization in dry powder inhalers: A simulation study.
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剂量载荷条件和装置几何形状对干粉吸入器中传输和雾化的影响：一项模拟研究。
DOI：
10.1016/j.ijpharm.2021.121219
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发表时间：
2021-12-15
影响因子：
5.8
通讯作者：
Sundaresan, Sankaran
中科院分区：
文献类型：
--
作者：
Sulaiman, Mostafa;Liu, Xiaoyu;Sundaresan, Sankaran
关键词：
通过计算流体力学-离散元方法(CFD-DEM)模拟研究了几种不同几何形状的干粉吸入器中颗粒的输运和气雾化。这些模拟将气体的大涡模拟与所有载体颗粒和活性药物成分(API)颗粒的代表性子集的离散元模型模拟结合在一起。本研究的目的是探索导致API颗粒释放的主要机理，并论证CFD-DEM模拟的价值，即跟踪所有载体和API颗粒的运动。模拟是在不同的吸入率和初始剂量加载条件下进行的，分别是屏蔽式吸入器、简单的圆柱管吸入器和采取凹凸壁和挡板形式的五种不同的几何改进器。这些几何形状的改变改变了粉末样品在吸入器中的停留时间、整个吸入器的压降、气体-载体相互作用的严重程度以及载体颗粒经历的碰撞次数，所有这些都是量化的。研究发现，气雾化的质量与航母的平均滑移速度有关，而碰撞只起到次要作用。一些几何形状的修改改善了气雾化质量，而设备上的压降几乎没有增加。
The transport and aerosolization of particles are studied in several different dry powder inhaler geometries via Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) simulations. These simulations combine Large Eddy Simulation of gas with Discrete Element Model simulation of all the carrier particles and a representative subset of the active pharmaceutical ingredient (API) particles. The purpose of the study is to probe the dominant mechanism leading to the release of the API particles and to demonstrate the value of the CFD-DEM simulations where one tracks the motion of all the carrier and API particles. Simulations are performed at different inhalation rates and initial dose loading conditions for the screen-haler geometry, a simple cylindrical tube inhaler, and five different geometry modifications that took the form of bumpy walls and baffles. These geometry modifications alter the residence time of the powder sample in the inhaler, pressure drop across the inhaler, the severity of gas-carrier interactions, and the number of collisions experienced by the carrier particles, all of which are quantified. The quality of aerosolization is found to correlate with the average air-carrier slip velocity, while collisions played only a secondary role. Some geometry modifications improved aerosolization quality with very little increase in the pressure drop across the device.
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影响因子：
3.3
作者：
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通讯作者：
Price, Robert
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2015-06-01
影响因子：
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