Bio-based elastomer nanoparticles with controllable biodegradability
Bio-based elastomer nanoparticles with controllable biodegradability
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具有可控生物降解性的生物基弹性体纳米颗粒
DOI：
10.1039/c6ra24336c
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Chengqun Niu
中科院分区：
文献类型：
--
作者：
Qingguo Wang;Yingying Zai;Dejing Yang;Liyan Qiu;Chengqun Niu
近年来，生物可降解聚合物和纳米聚合物已成为先进聚合物研究的热点。在本文中，我们通过三步法报道了一种新型的电子束辐照硫化软聚酯纳米颗粒。采用熔融缩聚法制备脂肪族不饱和聚酯，再经聚酯乳化和辐射交联得到弹性聚酯纳米粒子。有趣的是，具有凝胶含量可控、生物降解性可控(在脂肪酶存在下5天内失重率为52.3%)和低玻璃化转变温度(−55°C左右)的交联软聚酯纳米粒子不仅可以满足药物输送载体的要求，还可以用于修饰一些广泛应用于药学、生物技术和生物医学的可生物降解的脆性聚合物。
Recently, biodegradable polymers and nanoscale polymers have become hot topics in advanced polymer research. In this manuscript, we report novel electron beam irradiation vulcanized soft polyester nanoparticles through a three-step method. Some dicarboxylic acids (e.g., succinic acid, sebacic acid, itaconic acid) and diols (e.g., 1,3-propanediol and 1,4-butanediol), which can also be derived from biomass resources, were firstly synthesized into the aliphatic unsaturated polyester by using melt polycondensation, which was followed with polyester emulsification and radiation crosslinking to obtain the elastic polyester nanoparticles. Interestingly, the crosslinked soft polyester nanoparticles with controllable gel content, controllable biodegradability (exhibiting a weight loss ratio of 52.3% within 5 days in the presence of lipase) and low glass transition temperature of about −55 °C are potential candidates to meet the requirements not only for drug delivery carriers but also for modifying some biodegradable brittle polymers which are widely used in pharmaceutical sciences, biotechnology, and biomedicine.
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DOI：
10.1016/j.nano.2014.04.008
发表时间：
2014-10
期刊：
Nanomedicine : nanotechnology, biology, and medicine
影响因子：
--
作者：
E. Masaeli;P. Wieringa;M. Morshed;M. Nasr-Esfahani;Saeid Sadri;C. V. van Blitterswijk;L. Moroni
通讯作者：
E. Masaeli;P. Wieringa;M. Morshed;M. Nasr-Esfahani;Saeid Sadri;C. V. van Blitterswijk;L. Moroni
影响因子：
15
作者：
Ronghua Zheng;Guojun Liu;Xiao-hu Yan
通讯作者：
Ronghua Zheng;Guojun Liu;Xiao-hu Yan
DOI：
10.1080/09205063.2013.862400
发表时间：
2014-01
期刊：
Journal of Biomaterials Science, Polymer Edition
影响因子：
--
作者：
T. Volova;D. Goncharov;A. Sukovatyi;A. Shabanov;E. Nikolaeva;E. Shishatskaya
通讯作者：
T. Volova;D. Goncharov;A. Sukovatyi;A. Shabanov;E. Nikolaeva;E. Shishatskaya
影响因子：
29.4
作者：
Tawfick, Sameh;De Volder, Michael;Hart, A. John
通讯作者：
Hart, A. John
影响因子：
5.5
作者：
CHEN, YC;DIMONIE, V;ELASSER, MS
通讯作者：
ELASSER, MS