Oxytocin, a Novel Treatment for Methamphetamine Use Disorder.
Oxytocin, a Novel Treatment for Methamphetamine Use Disorder.
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DOI：
10.3390/neurolint14010015
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发表时间：
2022-01-30
影响因子：
3
通讯作者：
Kaye AD
中科院分区：
文献类型：
--
作者：
Edinoff AN;Thompson E;Merriman CE;Alvarez MR;Alpaugh ES;Cornett EM;Murnane KS;Kozinn RL;Shah-Bruce M;Kaye AM;Kaye AD
用催产素治疗药物滥用是解决一个具有挑战性的公共卫生问题的一种新方法，该问题继续导致全世界社会的经济成本不断增加。甲基苯丙胺成瘾是世界范围内死亡的主要原因之一，尽管在理解甲基苯丙胺成瘾的神经生物学方面取得了进展，但治疗选择有限。目前，美国食品和药物管理局还没有批准用于治疗兴奋剂使用障碍的药物。用于兴奋剂滥用的治疗的标签外使用包括抗抑郁药、抗焦虑药和作为替代药物的较温和的兴奋剂。由于这些试图治疗复杂的精神疾病的缺点，最近注意催产素治疗（OT）已获得势头，在社会压力，社会焦虑，社会认知和精神病的背景下，作为一种可能的治疗在临床研究。催产素增强了皮层区域之间的连接。在患有OT的啮齿动物中的研究结果表明，催产素的中枢神经调节可能有益于跨越兴奋剂依赖的过渡状态，并可能减轻强烈的戒断症状。对催产素与可卡因、大麻和酒精等其他药物滥用情况的研究也支持催产素治疗甲基苯丙胺类兴奋剂使用障碍的潜力。甲基安非他明滥用仍然是全世界痛苦和功能失调的一个重要原因。催产素对甲基苯丙胺使用的影响概述在这次审查中，应作为催化剂，进一步调查治疗兴奋剂使用障碍，甲基苯丙胺型催产素在人类的疗效。更多的基于人类的研究应该开始涉及长期疗效，副作用和患者选择的研究。
The treatment of substance abuse with oxytocin is a novel approach to a challenging public health issue that continues to contribute to a growing economic cost for societies worldwide. Methamphetamine addiction is one of the leading causes of mortality worldwide, and despite advances in understanding the neurobiology of methamphetamine addiction, treatment options are limited. There are no medications that the Food and Drug Administration currently approves for stimulant use disorder. Off-label use of therapies for stimulant misuse include antidepressants, anxiolytics, and milder stimulants as replacement agents. Due to the shortcomings of these attempts to treat a complicated psychiatric disorder, recent attention to oxytocin therapy (OT) has gained momentum in clinical studies as a possible therapy in the context of social stress, social anxiety, social cognition, and psychosis. Oxytocin produces enhanced connectivity between cortical regions. The results from studies in rodents with OT suggest that central neuromodulation of oxytocin may be beneficial across transition states of stimulant dependence and may alleviate intense withdrawal symptoms. Studies of oxytocin in the context of other drugs of abuse, including cocaine, cannabis, and alcohol, also support the potential of oxytocin to treat stimulant use disorder, methamphetamine type. Methamphetamine abuse continues to be a significant cause of distress and dysfunction throughout the world. The effects of oxytocin on methamphetamine use outlined in this review should act as a catalyst for further investigation into the efficacy of treating stimulant use disorder, methamphetamine type with oxytocin in humans. More human-based research should initiate studies involving the long-term efficacy, side effects, and patient selection.
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影响因子：
10.6
作者：
Cox BM;Bentzley BS;Regen-Tuero H;See RE;Reichel CM;Aston-Jones G
通讯作者：
Aston-Jones G
影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
影响因子：
3.6
作者：
Everett, Nicholas;Baracz, Sarah;Cornish, Jennifer
通讯作者：
Cornish, Jennifer
影响因子：
4.8
作者：
Khoshbouei, H;Wang, HW;Galli, A
通讯作者：
Galli, A
影响因子：
3.3
作者：
Jan RK;Kydd RR;Russell BR
通讯作者：
Russell BR