Factors associated with anxiety disorder comorbidity.
Factors associated with anxiety disorder comorbidity.
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DOI：
10.1016/j.jad.2022.11.051
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发表时间：
2023-02-15
影响因子：
6.6
通讯作者：
Eley, Thalia C.
中科院分区：
文献类型：
--
作者：
Davies, Molly R.;Glen, Kiran;Mundy, Jessica;Ter Kuile, Abigail R.;Adey, Brett N.;Armour, Cherie;Assary, Elham;Coleman, Jonathan R., I;Goldsmith, Kimberley A.;Hirsch, Colette R.;Hotopf, Matthew;Hubel, Christopher;Jones, Ian R.;Kalsi, Gursharan;Krebs, Georgina;McIntosh, Andrew M.;Morneau-Vaillancourt, Genevieve;Peel, Alicia J.;Purves, Kirstin L.;Lee, Sang Hyuck;Skelton, Megan;Smith, Daniel J.;Veale, David;Walters, James T. R.;Young, Katherine S.;Zvrskovec, Johan;Breen, Gerome;Eley, Thalia C.
焦虑和抑郁障碍经常同时出现，它们出现的顺序可能与不同的临床结果有关。然而，关于焦虑-焦虑共病的研究很少。这项研究调查了与焦虑共病和焦虑-MDD时间序列相关的因素。在线，自我报告数据收集自英国的GREAD和COMPAING NBR队列(N=387,775)。Logistic回归分析比较了单一焦虑、焦虑-焦虑共病、焦虑-MDD(严重抑郁障碍)共病和仅有MDD的患者在社会人口学、创伤和临床因素上的差异。此外，还比较了焦虑优先和MDD优先焦虑-MDD。在那些有自我报告的家族史或基因数据的参与者中，评估了家族风险的差异。焦虑-焦虑和焦虑-MDD自我报告的焦虑症或抑郁障碍的诊断率更高，发病年龄更小，复发率比单一焦虑更高。焦虑症-MDD表现出比单纯MDD更严重的临床严重性/复杂性。焦虑-焦虑比焦虑-MDD有更严重的当前焦虑症状，不那么严重的当前抑郁症状，以及自我报告焦虑/抑郁障碍诊断的可能性降低。焦虑为先焦虑-MDD比MDD-First有更年轻的发病年龄，更严重的焦虑症状，自我报告诊断的可能性更小。家族性风险的差异很小。自我报告、追溯性措施可能会导致回忆偏差。家族性风险分析可能力度不够。焦虑-焦虑共病表现出与焦虑-MDD类似的严重和复杂的症状，但有不同的特征。对于焦虑症-MDD，首次发病的焦虑症比MDD-First有更早的发病年龄和更严重的严重性。焦虑症和共病值得在研究和实践中进一步研究和关注。关于焦虑-焦虑共病的研究很少。焦虑-焦虑表现出与焦虑-MDD相似的严重/复杂的症状特征。焦虑-焦虑症患者的当前焦虑程度高于焦虑-MDD患者，但当前抑郁症状严重程度低于焦虑-焦虑患者。焦虑症-MDD首发焦虑症起病年龄更早，症状更严重。自我报告的诊断率较低可能表明对焦虑的认知度低于MDD。
Anxiety and depressive disorders often co-occur and the order of their emergence may be associated with different clinical outcomes. However, minimal research has been conducted on anxiety-anxiety comorbidity. This study examined factors associated with anxiety comorbidity and anxiety-MDD temporal sequence. Online, self-report data were collected from the UK-based GLAD and COPING NBR cohorts (N = 38,775). Logistic regression analyses compared differences in sociodemographic, trauma, and clinical factors between single anxiety, anxiety-anxiety comorbidity, anxiety-MDD (major depressive disorder) comorbidity, and MDD-only. Additionally, anxiety-first and MDD-first anxiety-MDD were compared. Differences in familial risk were assessed in those participants with self-reported family history or genotype data. Anxiety-anxiety and anxiety-MDD had higher rates of self-reported anxiety or depressive disorder diagnoses, younger age of onset, and higher recurrence than single anxiety. Anxiety-MDD displayed greater clinical severity/complexity than MDD only. Anxiety-anxiety had more severe current anxiety symptoms, less severe current depressive symptoms, and reduced likelihood of self-reporting an anxiety/depressive disorder diagnosis than anxiety-MDD. Anxiety-first anxiety-MDD had a younger age of onset, more severe anxiety symptoms, and less likelihood of self-reporting a diagnosis than MDD-first. Minimal differences in familial risk were found. Self-report, retrospective measures may introduce recall bias. The familial risk analyses were likely underpowered. Anxiety-anxiety comorbidity displayed a similarly severe and complex profile of symptoms as anxiety-MDD but distinct features. For anxiety-MDD, first-onset anxiety had an earlier age of onset and greater severity than MDD-first. Anxiety disorders and comorbidity warrant further investigation and attention in research and practice. Minimal research has been conducted on anxiety-anxiety comorbidity. Anxiety-anxiety displayed similarly severe/complex profiles of symptoms as anxiety-MDD. Anxiety-anxiety had higher current anxiety but lower current depressive symptom severity than anxiety-MDD. Anxiety-MDD first-onset anxiety had a younger age of onset and more severe symptoms. Lower self-reported diagnosis rates may indicate less recognition of anxiety than MDD.
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DOI：
10.1016/j.chc.2005.06.003
发表时间：
2005-10-01
影响因子：
2.4
作者：
Costello, EJ;Egger, HL;Angold, A
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DOI：
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1995-01-01
影响因子：
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DOI：
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发表时间：
2018-07
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
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作者：
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影响因子：
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