Repeat pregnancies among HIV-infected women enrolled in clinical trial PACTG1022.
Repeat pregnancies among HIV-infected women enrolled in clinical trial PACTG1022.
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参加临床试验 PACTG1022 的 HIV 感染妇女重复怀孕。
DOI：
10.1097/qai.0b013e3181a5b053
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Hitti,Jane
中科院分区：
文献类型：
--
作者：
Watts,DHeather;Huang,Sharon;Cohn,SusanE;Smith,Laura;Hitti,Jane
由于全球绝大多数HIV-1感染女性都处于生育年龄，因此该人群中有意怀孕和意外怀孕的发生相对频繁1，2，并且与早期相比，在高效抗逆转录病毒治疗（HAART）的背景下可能会增加。1，3许多HIV-1感染的妇女渴望生育。4然而，意外怀孕可能会导致发育中的胎儿意外暴露于潜在的致畸药物，如依法韦仑或未知风险的新药物。预防HIV-1感染妇女的意外妊娠是一个高度优先事项。我们评估了参加临床试验的妇女产后随访2年期间重复妊娠的发生率和潜在预测因素，该临床试验比较了妊娠期2种初始抗逆转录病毒治疗方案。这些妇女在怀孕期间和怀孕后进行了密集的随访，包括广泛的避孕咨询，并特别建议避免在研究中再次怀孕。我们假设重复怀孕的发生可能可以通过特定的人口统计学和/或临床特征来预测。通过识别这些特征，我们希望针对艾滋病毒感染的妇女最有可能再次怀孕，更有针对性的避孕咨询。
Because the great majority of HIV-1-infected women worldwide are of reproductive age, both intended and unintended pregnancies occur relatively frequently in this population 1, 2 and may be increasing in the context of highly active antiretroviral therapy (HAART) compared with earlier eras. 1, 3 Many HIV-1-infected women desire childbearing. 4 However, unintended pregnancies may result in inadvertent exposure of the developing fetus to potentially teratogenic drugs such as efavirenz or to newer medications of unknown risk. Prevention of unintended pregnancy among HIV-1-infected women is a high priority.We evaluated the rate and potential predictors of repeat pregnancy during 2 years of postpartum follow-up among women enrolled to a clinical trial that compared 2 initial antiretroviral regimens in pregnancy. These women had intensive follow-up during and after pregnancy, including extensive contraceptive counseling, and were specifically counseled to avoid subsequent pregnancies on study. We hypothesized that occurrence of repeat pregnancies might be predicted by specific demographic and/or clinical characteristics. By identifying these characteristics, we hoped to target HIV-infected women most at risk for repeat pregnancy with more focused contraceptive counseling.
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影响因子：
9.8
作者：
Stringer, Elizabeth M.;Kaseba, Christine;Stringer, Jeffrey A.
通讯作者：
Stringer, Jeffrey A.
成人无并发症疟疾的 CD4 T 细胞计数和 HIV-1 感染
DOI：
10.1097/01.qai.0000243125.98024.da
发表时间：
2006
期刊：
JAIDS Journal of Acquired Immune Deficiency Syndromes
影响因子：
--
作者：
J. V. Geertruyden;M. Mulenga;W. Kasongo;K. Polman;R. Colebunders;L. Kestens;U. d’Alessandro
通讯作者：
U. d’Alessandro
影响因子：
11.8
作者：
Chalwe V;Van geertruyden JP;Mukwamataba D;Menten J;Kamalamba J;Mulenga M;D'Alessandro U
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D'Alessandro U
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影响因子：
1.5
作者：
Kimberly C. Brouwer;Chunfu Yang;Shalini Parekh;L. Mirel;Y. Shi;J. Otieno;A. Lal;R. Lal
通讯作者：
R. Lal
影响因子：
3.3
作者：
van Eijk, AM;Ayisi, JG;Nahlen, BL
通讯作者：
Nahlen, BL