Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms.
Musculoskeletal Deficits and Cognitive Impairment: Epidemiological Evidence and Biological Mechanisms.
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DOI：
10.1007/s11914-022-00736-9
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发表时间：
2022-10
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
--
作者：
认知障碍与肥胖、肌肉减少症和骨质疏松症有关。然而，迄今为止，尚未发表关于肌肉骨骼缺陷与认知障碍之间关系的文献，重点是流行病学证据和生物学机制。在此，我们批判性地评估了过去3年发表的文献，强调了有趣和重要的新发现，并提供了未来方向的概述，这将提高我们对大脑和肌肉骨骼系统之间联系的理解。最近的文献表明，肌肉骨骼缺陷和认知障碍共享病理生理途径和风险因素。细胞因子和激素影响大脑和肌肉骨骼系统;然而，缺乏统一的定义和标准使得难以比较研究。旨在改善肌肉骨骼健康的干预措施是预防或减缓认知障碍的合理手段。我们强调了几种在这方面显示潜力的肌肉骨骼健康干预措施。
Cognitive impairment is associated with obesity, sarcopenia, and osteoporosis. However, no critical appraisal of the literature on the relationship between musculoskeletal deficits and cognitive impairment, focusing on the epidemiological evidence and biological mechanisms, has been published to date. Herein, we critically evaluate the literature published over the past 3 years, emphasizing interesting and important new findings, and provide an outline of future directions that will improve our understanding of the connections between the brain and the musculoskeletal system. Recent literature suggests that musculoskeletal deficits and cognitive impairment share pathophysiological pathways and risk factors. Cytokines and hormones affect both the brain and the musculoskeletal system; yet, lack of unified definitions and standards makes it difficult to compare studies. Interventions designed to improve musculoskeletal health are plausible means of preventing or slowing cognitive impairment. We highlight several musculoskeletal health interventions that show potential in this regard.
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DOI：
10.1073/pnas.1900544116
发表时间：
2019-08-06
影响因子：
11.1
作者：
Delezie, Julien;Weihrauch, Martin;Handschin, Christoph
通讯作者：
Handschin, Christoph
影响因子：
6.2
作者：
Bliuc, Dana;Tran, Thach;Center, Jacqueline R.
通讯作者：
Center, Jacqueline R.
影响因子：
6.2
作者：
Cui, Shun;Xiong, Fei;Hong, Yan;Jung, Ji-Ung;Li, Xing-Sheng;Liu, Jian-Zhong;Yan, Riqiang;Mei, Lin;Feng, Xu;Xiong, Wen-Cheng
通讯作者：
Xiong, Wen-Cheng
影响因子：
6.3
作者：
Beeri MS;Leugrans SE;Delbono O;Bennett DA;Buchman AS
通讯作者：
Buchman AS
影响因子：
3.3
作者：
Baker, Richelle;Coenen, Pieter;Straker, Leon
通讯作者：
Straker, Leon