Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.
Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.
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骨质疏松症与阿尔茨海默氏症、轻度认知障碍和认知功能下降有关。
DOI：
10.1111/jgs.17206
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发表时间：
2021-07
影响因子：
6.3
通讯作者：
Buchman AS
中科院分区：
文献类型：
--
作者：
Beeri MS;Leugrans SE;Delbono O;Bennett DA;Buchman AS
我们检查了肌肉减少症是否与晚年认知障碍的发生有关。非痴呆老年人 (N = 1175) 每年接受 17 项认知测试，汇总为总体认知评分。根据生物电阻抗测量的肌肉质量和基于握力的肌肉功能构建了肌肉减少症综合评分。采用 Cox 比例风险模型来检查肌肉减少症与阿尔茨海默氏痴呆 (AD) 和轻度认知障碍 (MCI) 的关联。线性混合效应模型确定了肌肉减少症与认知能力下降的关联。所有模型均控制了年龄、性别、教育程度、种族和身高的平方。平均随访时间为 5.6 年。基线时更严重的肌少症与更高的 AD 风险（风险比 [HR]，1.50 [95% 置信区间 1.20–1.86]；p < 0.001）和 MCI（1.21 [1.01–1.45]；0.04）和更快的认知衰退率相关（估计 =0.013；p = 0.01）。对肌肉减少症各个组成部分的分析表明，肌肉功能与 AD 事件、MCI 事件和认知能力下降相关，无论模型中是否有瘦肌肉质量项。相比之下，当模型中包含肌肉功能术语时，瘦肌肉质量与认知障碍或认知下降无关。肌肉功能不佳，但并未减少瘦肌肉质量，导致肌肉减少症与晚年认知障碍相关。需要进一步的工作来确定肌肉结构的特征，这可能会增加肌肉减少症的特异性，以识别有晚年认知障碍风险的老年人。
We examined whether sarcopenia is associated with the occurrence of late-life cognitive impairment. Nondemented older adults (N = 1175) underwent annual testing with 17 cognitive tests summarized as a global cognitive score. A composite sarcopenia score was constructed based on muscle mass measured with bioelectrical impedance and muscle function based on grip strength. Cox proportional hazard models were employed to examine associations of sarcopenia with incident Alzheimer's dementia (AD) and incident mild cognitive impairment (MCI). Linear mixed-effect models determined the association of sarcopenia with cognitive decline. All models controlled for age, sex, education, race, and height squared. Average follow-up was 5.6 years. More severe sarcopenia at baseline was associated with a higher risk of incident AD (hazard ratio [HR], 1.50 [95% confidence interval 1.20–1.86]; p < 0.001) and of MCI (1.21 [1.01–1.45]; 0.04) and a faster rate of cognitive decline (estimate =0.013; p = 0.01). Analyses of the individual components of sarcopenia showed that muscle function was associated with incident AD, incident MCI, and cognitive decline with and without a term for lean muscle mass in the model. In contrast, lean muscle mass was not associated with incident cognitive impairment or cognitive decline when a term for muscle function was included in the model. Poor muscle function, but not reduced lean muscle mass, drives the association of sarcopenia with late-life cognitive impairment. Further work is needed to identify features of muscle structure, which may increase the specificity of sarcopenia for identifying older adults at risk for late-life cognitive impairment.
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影响因子：
6.3
作者：
Cawthon PM;Manini T;Patel SM;Newman A;Travison T;Kiel DP;Santanasto AJ;Ensrud KE;Xue QL;Shardell M;Duchowny K;Erlandson KM;Pencina KM;Fielding RA;Magaziner J;Kwok T;Karlsson M;Ohlsson C;Mellström D;Hirani V;Ribom E;Correa-de-Araujo R;Bhasin S
通讯作者：
Bhasin S
DOI：
10.3233/jad-179939
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Bennett DA;Buchman AS;Boyle PA;Barnes LL;Wilson RS;Schneider JA
通讯作者：
Schneider JA
影响因子：
3.3
作者：
Cederholm, Tommy E.;Bauer, Juergen M.;Rolland, Yves
通讯作者：
Rolland, Yves
影响因子：
16.2
作者：
Sam, Susan;Haffner, Steven;Mazzone, Theodore
通讯作者：
Mazzone, Theodore
影响因子：
3.3
作者：
Janssen, I;Heymsfield, SB;Ross, R
通讯作者：
Ross, R