High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19.
High levels of von Willebrand factor with reduced specific activities in hospitalized patients with or without COVID-19.
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DOI：
10.1007/s11239-022-02679-5
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发表时间：
2022-08
影响因子：
4
通讯作者：
Rumbaut, Rolando E.
中科院分区：
文献类型：
--
作者：
Bray, Monica;Guzel, Melda A.;Lam, Fong;Yee, Andrew;Cruz, Miguel A.;Rumbaut, Rolando E.
COVID-19大流行通常伴有严重呼吸道疾病和血栓性并发症。血管性血友病因子（VWF）水平在这种情况下高度升高。然而，关于VWF在COVID-19中的定性活性的数据有限。我们定量（VWF抗原）和定性（瑞斯托菌素诱导的血小板凝集、糖蛋白IbM（GPIbM）结合和胶原结合）测定血浆VWF水平。与之前的报告一致，在有或没有COVID-19的住院患者中，VWF抗原水平显著升高。GPIbM和胶原结合活性与抗原的比值显著降低，与COVID-19中VWF的定性变化一致。值得注意的是，未患COVID-19的重症住院患者的VWF活性与抗原比值的降低与COVID-19患者相似。我们的数据表明，COVID-19中VWF的质的变化可能不是COVID-19特有的。未来的研究有必要确定COVID-19和其他危重疾病中VWF发生质的变化的机制。·与健康对照相比，COVID-19中的VWF水平升高。·与健康对照组相比，COVID-19中VWF活性与抗原的比值降低。·有或没有COVID-19的住院患者之间的VWF活性与抗原比率没有差异。·这些发现与全身性炎症中VWF的定性变化一致，而这种变化并非COVID-19所特有。未来的研究需要确定构象或多聚体长度变化在全身性炎症中VWF定性变化中的可能作用。在线版本包含补充材料，可通过10.1007/s11239-022-02679-5获得。
The COVID-19 pandemic is often accompanied by severe respiratory illness and thrombotic complications. Von Willebrand Factor (VWF) levels are highly elevated in this condition. However, limited data are available on the qualitative activity of VWF in COVID-19. We measured plasma VWF levels quantitatively (VWF antigen) and qualitatively (ristocetin-induced platelet agglutination, glycoprotein IbM (GPIbM) binding, and collagen binding). Consistent with prior reports, VWF antigen levels were significantly elevated in hospitalized patients with or without COVID-19. The GPIbM and collagen binding activity-to-antigen ratios were significantly reduced, consistent with qualitative changes in VWF in COVID-19. Of note, critically ill hospitalized patients without COVID-19 had similar reductions in VWF activity-to-antigen ratios as patients with COVID-19. Our data suggest that qualitative changes in VWF in COVID-19 may not be specific to COVID-19. Future studies are warranted to determine the mechanisms responsible for qualitative changes in VWF in COVID-19 and other critical illnesses. • VWF levels were increased in COVID-19 compared to healthy controls. • VWF activity-to-antigen ratios were decreased in COVID-19 compared to healthy controls. • There were no differences in VWF activity-to-antigen ratios between hospitalized patients with or without COVID-19. • These findings are consistent with qualitative changes in VWF in systemic inflammation which are not specific to COVID-19. • Future studies are needed to define possible roles of changes in conformation or multimer length in the qualitative changes in VWF in systemic inflammation. The online version contains supplementary material available at 10.1007/s11239-022-02679-5.
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DOI：
10.1111/jth.15409
发表时间：
2021-08
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Ward SE;Fogarty H;Karampini E;Lavin M;Schneppenheim S;Dittmer R;Morrin H;Glavey S;Ni Cheallaigh C;Bergin C;Martin-Loeches I;Mallon PW;Curley GF;Baker RI;Budde U;O'Sullivan JM;O'Donnell JS;Irish COVID-19 Vasculopathy Study (iCVS) investigators
通讯作者：
Irish COVID-19 Vasculopathy Study (iCVS) investigators
影响因子：
3.9
作者：
Nossent JC;Raymond WD;Eilertsen GØ
通讯作者：
Eilertsen GØ
影响因子：
9.3
作者：
Flood, Veronica H.;Gill, Joan Cox;Haberichter, Sandra L.
通讯作者：
Haberichter, Sandra L.
影响因子：
10.4
作者：
Mancini, Ilaria;Baronciani, Luciano;Peyvandi, Flora
通讯作者：
Peyvandi, Flora
影响因子：
20.3
作者：
Yee, Andrew;Gildersleeve, Robert D.;Ginsburg, David
通讯作者：
Ginsburg, David