Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection.
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection.
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DOI：
10.1186/1475-2875-7-113
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发表时间：
2008-06-26
期刊：
影响因子：
3
通讯作者：
Looareesuwan S
中科院分区：
文献类型：
--
作者：
Nagao Y;Kimura-Sato M;Chavalitshewinkoon-Petmitr P;Thongrungkiat S;Wilairatana P;Ishida T;Tan-Ariya P;de Souza JB;Krudsood S;Looareesuwan S
据报道，间日疟原虫可抑制恶性疟原虫，并可改善同时感染这两种疟原虫的患者的疾病严重程度。作者研究了间日疟原虫刺激的免疫反应可能在抑制恶性疟原虫混合感染中发挥作用的假说。将实验感染间日疟原虫时取自作者之一(YN)的血清加入恶性疟原虫体外培养物中。检测血清中抗恶性疟原虫抗原的交叉反应抗体和细胞因子。在急性发作期间收集的血清对恶性疟原虫培养物有显著的生长抑制作用(与发病前的平均水平相比，最大抑制率为68%)。这种抑制作用与交叉反应抗体，特别是抗恶性疟原虫裂殖体提取物的IgM，以及较小程度的抗裂殖子表面蛋白(MSP)-119的IgM呈强的时间正相关。在志愿者中，白介素12与间日疟原虫血症和体温的时间相关性最高。这些结果表明，交叉反应抗体，特别是IgM，参与了疟原虫物种之间的相互作用。IL-12可能是间日疟原虫裂殖体破裂引起发热的直接介质之一，至少在某些受试者中是如此。未来的研究，最好是流行病学设计，以揭示交叉反应性IgM和交叉疟原虫相互作用之间的关联是有必要的。
It has frequently been reported that Plasmodium vivax suppressed Plasmodium falciparum and ameliorated disease severity in patients infected with these two species simultaneously. The authors investigate the hypothesis that immunological responses stimulated by P. vivax may play a role in suppressing co-infecting P. falciparum. Sera, taken sequentially from one of the authors (YN) during experimental infection with P. vivax, were added to in vitro cultures of P. falciparum. Cross-reactive antibodies against P. falciparum antigens, and cytokines were measured in the sera. Significant growth inhibitory effects upon P. falciparum cultures (maximally 68% inhibition as compared to pre-illness average) were observed in the sera collected during an acute episode. Such inhibitory effects showed a strong positive temporal correlation with cross-reactive antibodies, especially IgM against P. falciparum schizont extract and, to a lesser degree, IgM against Merozoite Surface Protein (MSP)-119. Interleukin (IL)-12 showed the highest temporal correlation with P. vivax parasitaemia and with body temperatures in the volunteer. These results suggest the involvement by cross-reactive antibodies, especially IgM, in the interplay between plasmodial species. IL-12 may be one of direct mediators of fever induction by rupturing P. vivax schizonts, at least in some subjects. Future studies, preferably of epidemiological design, to reveal the association between cross-reactive IgM and cross-plasmodial interaction, are warranted.
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影响因子：
2.2
作者：
Favre, N;Ryffel, B;Rudin, W
通讯作者：
Rudin, W
影响因子：
3.1
作者：
Choudhury, HR;Sheikh, NA;De Souza, JB
通讯作者：
De Souza, JB
DOI：
10.1016/s0035-9203(97)90066-3
发表时间：
1997-05-01
影响因子：
2.2
作者：
Luxemburger, C;Ricci, F;White, N
通讯作者：
White, N
DOI：
10.1016/s0035-9203(96)90406-x
发表时间：
1996-11-01
影响因子：
2.2
作者：
Maitland, K;Williams, TN;Bowden, DK
通讯作者：
Bowden, DK
DOI：
10.4269/ajtmh.1994.51.785
发表时间：
1994-12-01
影响因子：
3.3
作者：
DUC, DD;DEVRIES, PJ;VANBOXTEL, CJ
通讯作者：
VANBOXTEL, CJ