Clinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling.
Clinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling.
复制标题
DOI：
10.1016/j.semcdb.2011.10.014
复制
发表时间：
2012-02
影响因子：
7.3
通讯作者：
Brantley-Sieders, Dana M.
中科院分区：
文献类型：
--
作者：
Brantley-Sieders, Dana M.
Pre-clinical studies provide compelling evidence that members of the Eph family of receptor tyrosine kinases and their ephrin ligands promote tumor growth, invasion and metastasis, and neovascularization. Tumor suppressive roles have also been reported for the receptors, and ligand-dependent versus ligand-independent signaling has emerged as one key mechanism underlying tumor suppressive function as opposed to oncogenic effects. Determining how these observations relate to clinical outcome is a crucial step for translating the biological and mechanistic data into new molecularly targeted therapies. Expression profiling in human patient samples bridges this gap and provides valuable clinical relevance to laboratory observations. In addition to analyses performed using privately assembled patient tumor samples, publically available microarray datasets and tissue microarrays linked to clinical data have emerged as tractable tools for addressing the clinical relevance of specific molecules and families of related molecules. This review summarizes the clinical relevance of specific Eph and ephrin molecules in human breast, colorectal, and lung cancers.
登录
查看更多内容
通过激活EGFR体细胞突变的非小细胞肺癌细胞的转录分析。
影响因子：
3.7
作者：
Choi, Kuicheon;Creighton, Chad J.;Stivers, David;Fujimoto, Nobukazu;Kurie, Jonathan M.
通讯作者：
Kurie, Jonathan M.
影响因子：
11.2
作者：
Brantley-Sieders DM;Dunaway CM;Rao M;Short S;Hwang Y;Gao Y;Li D;Jiang A;Shyr Y;Wu JY;Chen J
通讯作者：
Chen J
DOI：
10.1006/bbrc.1996.1442
发表时间：
1996-09-24
影响因子：
3.1
作者：
Berclaz, G;Andres, AC;Crompton, MR
通讯作者：
Crompton, MR
影响因子：
4.7
作者：
Alam, Syed Mahfuzul;Fujimoto, Jiro;Tamaya, Teruhiko
通讯作者：
Tamaya, Teruhiko
影响因子：
11.5
作者：
Brannan, Jennifer M.;Dong, Wenli;Johnson, Faye M.
通讯作者：
Johnson, Faye M.