Anti-inflammatory role of fenofibrate in treating diseases.
Anti-inflammatory role of fenofibrate in treating diseases.
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DOI：
10.17305/bb.2022.8534
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发表时间：
2023-05-01
期刊：
影响因子：
--
通讯作者：
Huang, Songming
中科院分区：
文献类型：
--
作者：
Jin, Lv;Hua, Hu;Ji, Yong;Jia, Zhanjun;Peng, Mingqi;Huang, Songming
关键词：
炎症有助于几种疾病的发病机制。非诺贝特是一种过氧化物酶体增殖物激活受体-α（peroxisome proliferator-activated receptor-α，PPAR-α）激动剂，是治疗高脂血症的经典药物。除降脂作用外，据报道非诺贝特还具有抗炎作用，其作用机制复杂。一般来说，非诺贝特的抗炎作用是继发于其降脂作用的，特别是对于高脂血症引起的循环系统炎症。其抗炎作用可能还与其通过激活PPAR-α调节细胞内脂质代谢有关。此外，其抗炎作用可能是通过直接调节炎症信号通路来实现的。为了更好地了解非诺贝特的抗炎活性及其在疾病中的作用机制，本文对非诺贝特在不同器官系统疾病中的抗炎作用及其机制进行了综述和讨论。因此，这篇综述提供了非诺贝特在临床环境中的最佳使用的见解。
Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating hyperlipidemia. In addition to its lipid-lowering effect, fenofibrate has also been reported to exert anti-inflammatory effects with complicated underlying mechanisms of action. In general, the anti-inflammatory effect of fenofibrate is secondary to its lipid-lowering effect, especially for the inflammation caused by hyperlipidemia in the circulatory system. Some anti-inflammatory actions may also come from its regulatory effects on intracellular lipid metabolism by activating PPAR-α. In addition, some roles in anti-inflammation might be mediated by its direct regulation of inflammatory signaling pathways. In order to understand anti-inflammatory activities and the underlying mechanisms of fenofibrate action in disease better, we herein reviewed and discussed the anti-inflammatory roles and its subserving mechanisms in various diseases of different organ systems. Thus, this review offers insights into the optimal use of fenofibrate in the clinical setting.
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