Role of Antioxidants and Natural Products in Inflammation.
Role of Antioxidants and Natural Products in Inflammation.
复制标题
DOI：
10.1155/2016/5276130
复制
发表时间：
2016
影响因子：
--
通讯作者：
Kumar SS
中科院分区：
文献类型：
--
作者：
Arulselvan P;Fard MT;Tan WS;Gothai S;Fakurazi S;Norhaizan ME;Kumar SS
炎症是对外来生物体（包括人类病原体、灰尘颗粒和病毒）的一系列综合性生理反应。根据不同的炎症过程和细胞机制，炎症主要分为急性和慢性炎症。最近的研究已经阐明，炎症是各种慢性疾病/病症（包括糖尿病、癌症、心血管疾病、眼部病症、关节炎、肥胖症、自身免疫性疾病和炎性肠病）进展的主要因素。来自不同生物和环境来源的自由基产生是由于天然抗氧化剂的不平衡，这进一步导致各种炎症相关疾病。在这篇综述文章中，我们概述了炎症过程及其细胞机制参与各种慢性现代人类疾病的进展。此外，我们还讨论了自由基诱导的组织损伤、抗氧化防御和慢性炎症性疾病/障碍的分子机制。关于炎症的作用及其相关不良反应的系统知识可以提供对来自天然来源的旨在抑制各种慢性炎症相关疾病的创新治疗靶点的开发的清晰理解。
Inflammation is a comprehensive array of physiological response to a foreign organism, including human pathogens, dust particles, and viruses. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. Recent investigations have clarified that inflammation is a major factor for the progression of various chronic diseases/disorders, including diabetes, cancer, cardiovascular diseases, eye disorders, arthritis, obesity, autoimmune diseases, and inflammatory bowel disease. Free radical productions from different biological and environmental sources are due to an imbalance of natural antioxidants which further leads to various inflammatory associated diseases. In this review article, we have outlined the inflammatory process and its cellular mechanisms involved in the progression of various chronic modern human diseases. In addition, we have discussed the role of free radicals-induced tissue damage, antioxidant defence, and molecular mechanisms in chronic inflammatory diseases/disorders. The systematic knowledge regarding the role of inflammation and its associated adverse effects can provide a clear understanding in the development of innovative therapeutic targets from natural sources that are intended for suppression of various chronic inflammations associated diseases.
登录
查看更多内容
影响因子：
--
作者：
Chun JM;Nho KJ;Kim HS;Lee AY;Moon BC;Kim HK
通讯作者：
Kim HK
影响因子：
2
作者：
Akihisa, T;Franzblau, SG;Kimura, Y
通讯作者：
Kimura, Y
影响因子：
0.7
作者：
Fard, Masoumeh Tangestani;Arulselvan, Palanisamy;Fakurazi, Sharida
通讯作者：
Fakurazi, Sharida
影响因子：
3.5
作者：
Chen, Zhuo;Liu, Yu-Mei;Zhou, Xia
通讯作者：
Zhou, Xia
影响因子：
3.7
作者：
Arulselvan P;Wen CC;Lan CW;Chen YH;Wei WC;Yang NS
通讯作者：
Yang NS