Membrane Transport Proteins Expressed in the Renal Tubular Epithelial Cells of Seawater and Freshwater Teleost Fishes.
Membrane Transport Proteins Expressed in the Renal Tubular Epithelial Cells of Seawater and Freshwater Teleost Fishes.
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DOI：
10.3389/fphys.2022.939114
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
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肾脏是海水和淡水硬骨鱼维持体液稳态的重要器官。海水硬骨鱼以少量等渗尿液排出硫酸盐和镁，淡水硬骨鱼以大量低渗透尿液排出水。尿液的体积、渗透压和离子组成主要由肾小管上皮细胞中表达的膜转运蛋白调节。对鱼肾的基因表达、免疫组织化学和功能分析发现，膜转运蛋白参与海水硬骨鱼近端小管分泌硫酸盐和镁离子、集合管减少尿量，以及淡水硬骨鱼远端小管和集合管以低渗尿形式排泄水。这些研究促进了人们对肾脏如何在分子水平上促进硬骨鱼海水和淡水适应的理解。
The kidney is an important organ that maintains body fluid homeostasis in seawater and freshwater teleost fishes. Seawater teleosts excrete sulfate and magnesium in small amounts of isotonic urine, and freshwater teleosts excrete water in large amounts of hypo-osmotic urine. The volume, osmolality, and ionic compositions of the urine are regulated mainly by membrane transport proteins expressed in the renal tubular epithelial cells. Gene expression, immunohistochemical, and functional analyses of the fish kidney identified membrane transport proteins involved in the secretion of sulfate and magnesium ions by the proximal tubules and reduction of urine volume by the collecting ducts in seawater teleosts, and excretion of water as hypotonic urine by the distal tubules and collecting ducts in freshwater teleosts. These studies promote an understanding of how the kidney contributes to the seawater and freshwater acclimation of teleosts at the molecular level.
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DOI：
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发表时间：
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影响因子：
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