Prospects for immunotherapy and vaccines against Cryptosporidium.
Prospects for immunotherapy and vaccines against Cryptosporidium.
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DOI：
10.4161/hv.28485
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发表时间：
2014
影响因子：
4.8
通讯作者：
Mead JR
中科院分区：
文献类型：
--
作者：
Mead JR
隐孢子虫是一种普遍存在的寄生虫，长期以来被认为是人类原虫腹泻的常见原因。虽然免疫活性宿主的感染通常是自限性的，但免疫功能低下的个体可发展为严重的、慢性的和危及生命的疾病。由于缺乏有效的药物治疗，预防疾病或降低感染严重程度的疫苗开发或免疫疗法是一个相关的选择。特别是，发展中国家的儿童可能从疫苗中受益最多，因为据报道，儿童早期的隐孢子虫病与随后的生长，身体健康和智力障碍有关。在这篇综述中，已被用于临床的免疫疗法，以及实验疫苗和它们的体内评价。
Cryptosporidium spp is a ubiquitous parasite that has long been recognized as a frequent cause of protozoal diarrhea in humans. While infections in immunocompetent hosts are usually self-limiting, immunocompromised individuals can develop severe, chronic, and life-threatening illness. Vaccine development or immunotherapy that prevents disease or reduces the severity of infection is a relevant option since efficacious drug treatments are lacking. In particular, children in developing countries might benefit the most from a vaccine since cryptosporidiosis in early childhood has been reported to be associated with subsequent impairment in growth, physical fitness, and intellectual capacity. In this review, immunotherapies that have been used clinically are described as well as experimental vaccines and their evaluation in vivo.
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影响因子：
29.4
作者：
Chen, XM;Levine, SA;LaRusso, NF
通讯作者：
LaRusso, NF
影响因子：
2.2
作者：
Ehigiator, HN;McNair, N;Mead, JR
通讯作者：
Mead, JR
DOI：
10.4269/ajtmh.2012.11-0273
发表时间：
2012-02-01
影响因子：
3.3
作者：
Borad, Anoli J.;Allison, Geneve M.;Ward, Honorine D.
通讯作者：
Ward, Honorine D.
多种 TLRs 在人胆管细胞中表达，并通过激活 NF-κB 介导宿主上皮细胞对副隐孢子虫的防御反应
影响因子：
4.4
作者：
Chen, XM;O'Hara, SP;LaRusso, NF
通讯作者：
LaRusso, NF
影响因子：
--
作者：
Benitez, Alvaro J.;McNair, Nina;Mead, Jan R.
通讯作者：
Mead, Jan R.