Adolescent substance use and high school noncompletion: exploring the nature of the relationship using a discordant twin design.
Adolescent substance use and high school noncompletion: exploring the nature of the relationship using a discordant twin design.
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青少年物质使用和高中未完成学业：使用不和谐的双胞胎设计探索关系的本质。
DOI：
10.1111/add.15996
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Slutske,WendyS
中科院分区：
文献类型：
--
作者：
Davis,ChristalN;Gizer,IanR;Lynskey,MichaelT;Statham,DixieJ;Heath,AndrewC;Martin,NicholasG;Slutske,WendyS
背景和目的以前的研究已经证明了物质使用与教育程度下降之间的关联；然而，许多研究无法解释潜在的混杂因素，如遗传和抚养环境。在少数控制这些因素的研究中，评估的物质仅限于酒精、大麻和烟草。为了解决这些局限性，我们在澳大利亚双胞胎的大样本中检验了青少年使用七种物质、额外使用的物质的数量和高中未完成的关系。设计采用一系列两水平广义混合效应Logistic回归分析来检验青少年使用物质和高中未完成之间的关系。背景澳大利亚参与者来自澳大利亚双胞胎登记的两个队列的9579名澳大利亚成年双胞胎。测量高中完成率、儿童严重抑郁、品行障碍症状、物质使用开始、人口学、在使用镇静剂(OR[OR] = 22.39[95%可信区间= 1.18-423.48])和吸入剂/溶剂(OR = 10.46[95%CI= 1.30-84.16])对高中学业不全的影响方面，存在独特的双胞胎效应。在所有不和谐的双胞胎模型中，青春期使用的物质的数量与高中阶段的不完成密切相关(OR从1.50-2.32，P<；0.03)。结论在澳大利亚，青少年使用物质似乎与早期辍学有关，任何特定物质的影响在很大程度上是由于父母教育、儿童行为障碍症状和使用其他物质的混杂因素。镇静剂和吸入剂/溶剂对高中未完成学业的影响不能用多种物质的使用或家庭因素解释。
Background and AimsPrevious studies have demonstrated associations between substance use and reduced educational attainment; however, many were unable to account for potential confounding factors like genetics and the rearing environment. In the few studies that controlled for these factors, the substances assessed were limited to alcohol, cannabis, and tobacco. To address these limitations, we examined the relationship between adolescent use of seven kinds of substances, the number of additional substances used, and high school noncompletion within a large sample of Australian twins.DesignA series of two‐level generalized mixed effects logistic regressions were conducted to examine associations between adolescent substance use and high school noncompletion.SettingAustralia.ParticipantsA total of 9579 adult Australian twins from two cohorts of the Australian Twin Registry.MeasurementsAssessments of high school completion, childhood major depression, conduct disorder symptoms, substance use initiation, demographics, and parental educational attainment using the Australian version of the Semi‐Structured Assessment for the Genetics of Alcoholism.FindingsThere were unique within‐twin‐pair effects of use of sedatives (odds ratio [OR] = 22.39 [95% confidence interval (CI) = 1.18–423.48]) and inhalants/solvents (OR = 10.46 [95% CI = 1.30–84.16]) on high school noncompletion. The number of substances used in adolescence was strongly associated with high school noncompletion across all discordant twin models (ORs from 1.50–2.32,Ps< 0.03).ConclusionsIn Australia, adolescent substance use appears to be associated with early school dropout, with the effects of any given substance largely because of the confounding factors of parental education, childhood conduct disorder symptoms, and use of other substances. Sedatives and inhalants/solvents have effects on high school noncompletion that cannot be explained by polysubstance use or familial factors.
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10.1016/0006-291x(79)91834-5
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