Extracellular vesicles in virus infection and pathogenesis.
Extracellular vesicles in virus infection and pathogenesis.
复制标题
病毒感染及致病机制中的细胞外囊泡。
DOI：
10.1016/j.coviro.2020.07.014
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发表时间：
2020-10
影响因子：
5.9
通讯作者：
Dittmer DP
中科院分区：
文献类型：
--
作者：
McNamara RP;Dittmer DP
Viruses are obligate intracellular parasites that usurp cellular signaling networks to promote pathogen spread and disease progression. Signaling through extracellular vesicles (EVs) is an emerging field of study in the virus-host interaction network. EVs relay information both locally and distally through incorporated contents, typically without tripping innate immune sensors. Therefore, this extracellular signaling axis presents itself as a tantalizing target for promoting a favorable niche for the pathogen(s) takeover of the host, particularly for chronic infections. From the incorporation of virus-encoded molecules such as micro RNAs and proteins/enzymes to the envelopment of entire infectious particles, evolutionary distinct viruses have shown a remarkable ability to converge on this means of communication. In this review, we will cover the recent advances in this field and explore how EV can be used as potential biomarkers for chronic, persistent, or latent virus infections. Extracellular vesicles are realeased by all cell types and transfer internal contents from one cell to the next. Viruses can mocify these internal contents, thereby influrncing recipient cell physiology without infection.
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影响因子：
5.2
作者：
Bello-Morales R;López-Guerrero JA
通讯作者：
López-Guerrero JA
影响因子：
6.7
作者：
Collins DR;Collins KL
通讯作者：
Collins KL
影响因子：
4.6
作者：
Boeske, Alexandra;Schwarten, Melanie;Willbold, Dieter
通讯作者：
Willbold, Dieter
影响因子：
64.5
作者：
AIKEN, C;KONNER, J;TRONO, D
通讯作者：
TRONO, D
影响因子：
4.4
作者：
del Rio-Iniguez, Iratxe;Vazquez-Chavez, Elena;Alcover, Andres
通讯作者：
Alcover, Andres