Extracellular Vesicles in Herpes Viral Spread and Immune Evasion.
Extracellular Vesicles in Herpes Viral Spread and Immune Evasion.
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DOI：
10.3389/fmicb.2018.02572
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发表时间：
2018
影响因子：
5.2
通讯作者：
López-Guerrero JA
中科院分区：
文献类型：
--
作者：
Bello-Morales R;López-Guerrero JA
细胞外囊泡（EVs）在包膜和非包膜病毒感染过程中参与了许多过程。其中，1型单纯疱疹病毒（HSV-1）调节分泌途径，使ev能够离开被感染的细胞。关于病毒传播机制的许多特征仍未确定，因此，分泌囊泡因其在病毒感染期间细胞间通讯中的作用而成为有希望的候选者。ev的另一个相关作用是保护病毒粒子免受中和抗体的作用，从而增加它们在宿主血液传播过程中的稳定性。最近的研究表明，ev参与了HSV-1的传播，其中受感染细胞释放的含有病毒粒子的微囊泡（mv）被naïve细胞内吞，导致生产感染。这提示HSV-1可能利用mv扩大其向性并逃避宿主免疫反应。在这篇综述中，我们简要描述了目前关于ev参与病毒感染的知识，并特别关注了它们在HSV-1传播中的作用的最新研究。自噬途径在ev的生物发生和分泌中的意义也将被讨论。
Extracellular vesicles (EVs) are involved in numerous processes during infections by both enveloped and non-enveloped viruses. Among them, herpes simplex virus type-1 (HSV-1) modulates secretory pathways, allowing EVs to exit infected cells. Many characteristics regarding the mechanisms of viral spread are still unidentified, and as such, secreted vesicles are promising candidates due to their role in intercellular communications during viral infection. Another relevant role for EVs is to protect virions from the action of neutralizing antibodies, thus increasing their stability within the host during hematogenous spread. Recent studies have suggested the participation of EVs in HSV-1 spread, wherein virion-containing microvesicles (MVs) released by infected cells were endocytosed by naïve cells, leading to a productive infection. This suggests that HSV-1 might use MVs to expand its tropism and evade the host immune response. In this review, we briefly describe the current knowledge about the involvement of EVs in viral infections in general, with a specific focus on recent research into their role in HSV-1 spread. Implications of the autophagic pathway in the biogenesis and secretion of EVs will also be discussed.
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影响因子：
64.8
作者：
Feng Z;Hensley L;McKnight KL;Hu F;Madden V;Ping L;Jeong SH;Walker C;Lanford RE;Lemon SM
通讯作者：
Lemon SM
影响因子：
7.3
作者：
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通讯作者：
Yáñez-Mó M
影响因子：
5.4
作者：
Buckingham EM;Jarosinski KW;Jackson W;Carpenter JE;Grose C
通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
Altan-Bonnet N
影响因子：
7.3
作者：
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通讯作者：
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