Perception and memory have distinct spatial tuning properties in human visual cortex.
Perception and memory have distinct spatial tuning properties in human visual cortex.
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DOI：
10.1038/s41467-022-33161-8
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发表时间：
2022-10-18
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
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早期知觉活动的重新激活被认为是长期记忆回忆的基础。尽管有证据支持这一观点，但目前还不清楚记忆活动是否表现出与前馈感知活动相同的调谐特性。在这里，我们利用人口感受野模型参数化的功能磁共振成像活动在人类视觉皮层空间记忆检索。虽然在感知和记忆过程中都存在视网膜组织，但调谐中的大系统差异也很明显。虽然在感知过程中，从早期到晚期视觉区域的空间精度下降了三倍，但在记忆提取过程中没有观察到这种模式。这种差异不能用信噪比降低或记忆试验性能差来解释。相反，通过模拟自上而下的活动在网络模型的皮层，我们证明，这一属性是很好地解释了视觉系统的层次结构。总之，建模和实证结果表明，视觉系统架构所施加的计算约束限制了感觉皮层记忆激活的保真度。来自感知的神经活动被认为在记忆回忆过程中被重新激活。在这里，作者表明，视觉皮层的记忆再激活表现出与感知过程中观察到的不同的调谐特性。
Reactivation of earlier perceptual activity is thought to underlie long-term memory recall. Despite evidence for this view, it is unclear whether mnemonic activity exhibits the same tuning properties as feedforward perceptual activity. Here, we leverage population receptive field models to parameterize fMRI activity in human visual cortex during spatial memory retrieval. Though retinotopic organization is present during both perception and memory, large systematic differences in tuning are also evident. Whereas there is a three-fold decline in spatial precision from early to late visual areas during perception, this pattern is not observed during memory retrieval. This difference cannot be explained by reduced signal-to-noise or poor performance on memory trials. Instead, by simulating top-down activity in a network model of cortex, we demonstrate that this property is well explained by the hierarchical structure of the visual system. Together, modeling and empirical results suggest that computational constraints imposed by visual system architecture limit the fidelity of memory reactivation in sensory cortex. Neural activity from perception is thought to be reactivated during memory recall. Here, the authors show that memory reactivation in visual cortex exhibits different tuning properties from those observed during perception.
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影响因子：
15.9
作者：
Favila SE;Lee H;Kuhl BA
通讯作者：
Kuhl BA
影响因子：
16.6
作者：
Bone, Michael B.;Ahmad, Fahad;Buchsbaum, Bradley R.
通讯作者：
Buchsbaum, Bradley R.
DOI：
10.1073/pnas.0404965101
发表时间：
2004-09-07
影响因子：
11.1
作者：
Gallistel, CR;Fairhurst, S;Balsam, P
通讯作者：
Balsam, P
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
7.7
作者：
Dijkstra, Nadine;Ambrogioni, Luca;van Gerven, Marcel
通讯作者：
van Gerven, Marcel