Why is osteoarthritis an age-related disease?
Why is osteoarthritis an age-related disease?
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DOI：
10.1016/j.berh.2009.08.006
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发表时间：
2010-02
影响因子：
5.2
通讯作者：
Loeser, Richard F.
中科院分区：
文献类型：
--
作者：
Anderson, A. Shane;Loeser, Richard F.
虽然老年是OA的最大风险因素，但OA并不是衰老的必然结果。OA的影像学改变，特别是骨赘，在老年人群中很常见，但在许多老年人中，关节疼痛的症状可能与影像学严重程度无关。肌肉骨骼系统的老化变化增加了OA的倾向，但受影响的关节和疾病的严重程度与其他OA风险因素（如关节损伤、肥胖、遗传学和影响关节力学的解剖学因素）密切相关。关节组织中有助于OA发展的老化变化包括导致衰老分泌表型发展的细胞衰老和基质中的老化变化，包括影响关节组织机械特性的晚期糖基化终产物的形成。对关节衰老机制的进一步理解可能会揭示新的治疗靶点，以减缓或阻止疾病进展。考虑到我们人口的老龄化和其他OA风险因素（如肥胖）的增加，减缓老年人OA进展的能力将对公共卫生产生巨大影响。
Although older age is the greatest risk factor for OA, OA is not an inevitable consequence of growing old. Radiographic changes of OA, particularly osteophytes, are common in the aged population but symptoms of joint pain may be independent of radiographic severity in many older adults. Aging changes in the musculoskeletal system increase the propensity to OA but the joints affected and the severity of disease are most closely related to other OA risk factors such as joint injury, obesity, genetics, and anatomical factors that affect joint mechanics. The aging changes in joint tissues that contribute to the development of OA include cell senescence that results in development of the senescent secretory phenotype and aging changes in the matrix, including formation of advanced glycation end-products that affect the mechanical properties of joint tissues. An improved mechanistic understanding of joint aging will likely reveal new therapeutic targets to slow or halt disease progression. The ability to slow progression of OA in older adults will have enormous public health implications given the aging of our population and the increase in other OA risk factors such as obesity.
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影响因子：
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作者：
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通讯作者：
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作者：
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DOI：
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发表时间：
2002-11-20
影响因子：
6.2
作者：
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