Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work.
Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work.
复制标题
线粒体聚（ADP-核糖）聚合酶：工作中的绿野仙踪。
DOI：
10.1016/j.freeradbiomed.2016.02.024
复制
发表时间：
2016-11
影响因子：
7.4
通讯作者：
Szabo, Csaba
中科院分区：
文献类型：
--
作者：
Brunyanszki, Attila;Szczesny, Bartosz;Virag, Laszlo;Szabo, Csaba
在聚（ADP-核糖）聚合酶（PARP）家族的多个成员中，PARP 1占哺乳动物细胞中PARP活性的大部分。虽然PARP 1主要定位于细胞核，其核调节作用是最常研究的，并且是最好的表征，但几条数据线表明PARP 1也存在于线粒体中，并表明线粒体PARP（mtPARP）在健康和疾病中的各种细胞功能的调节中起重要作用。本文综述了PARP 1的线粒体定位及其线粒体内功能的实验证据，重点介绍了细胞生物能量学、线粒体DNA修复和线粒体功能障碍。此外，我们还提出了一个工作模型的线粒体和核PARP在氧化剂诱导的细胞死亡的相互作用。MtPARP类似于绿野仙踪，它是神秘的，它已经难以捉摸了很长一段时间，它仍然很难被审问。mtPARP --至少在某些细胞类型中--作为许多重要细胞功能的协调者在“幕后”不断工作。
Among multiple members of the poly(ADP-ribose) polymerase (PARP) family, PARP1 accounts for the majority of PARP activity in mammalian cells. Although PARP1 is predominantly localized to the nucleus, and its nuclear regulatory roles are most commonly studied and are the best characterized, several lines of data demonstrate that PARP1 is also present in the mitochondria, and suggest that mitochondrial PARP (mtPARP) plays an important role in the regulation of various cellular functions in health and disease. The goal of the current article is to review the experimental evidence for the mitochondrial localization of PARP1 and its intra-mitochondrial functions, with focus on cellular bioenergetics, mitochondrial DNA repair and mitochondrial dysfunction. In addition, we also propose a working model for the interaction of mitochondrial and nuclear PARP during oxidant-induced cell death. MtPARP is similar to the Wizard of Oz in the sense that it is enigmatic, it has been elusive for a long time and it remains difficult to be interrogated. mtPARP - at least in some cell types - works incessantly “behind the curtains” as an orchestrator of many important cellular functions.
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DOI：
10.1023/b:jobb.0000041755.22613.8d
发表时间：
2004-08-01
影响因子：
3
作者：
Dawson, VL;Dawson, TM
通讯作者：
Dawson, TM
DOI：
10.2741/3297
发表时间：
2009-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
David KK;Andrabi SA;Dawson TM;Dawson VL
通讯作者：
Dawson VL
影响因子：
3.6
作者：
Brunyanszki, Attila;Olah, Gabor;Szabo, Csaba
通讯作者：
Szabo, Csaba
影响因子：
7.4
作者：
Cadenas, E;Davies, KJA
通讯作者：
Davies, KJA
影响因子：
3.5
作者：
BANASIK, M;KOMURA, H;UEDA, K
通讯作者：
UEDA, K