Brain-derived adrenomedullin controls blood volume through the regulation of arginine vasopressin production and release.
Brain-derived adrenomedullin controls blood volume through the regulation of arginine vasopressin production and release.
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脑源性肾上腺髓质素通过调节精氨酸加压素的产生和释放来控制血容量。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
W. Samson
中科院分区：
文献类型：
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作者：
Meghan M. Taylor;Jennifer R. Baker;W. Samson
中枢神经系统来源的肾上腺髓质素（AM）已被证明是口渴的生理调节剂。管理AM到侧脑室的大脑衰减水的摄入量，而内源性AM的减少，诱导的AM特异性核酶，导致夸大的水的摄入量。我们推测，中央AM可能控制流体稳态，部分通过调节血浆精氨酸加压素（AVP）水平。为了验证这一假设，AM或特异性的核酶给药intracerebroventricularly，和血浆AVP浓度的变化进行了研究基础和刺激（低血容量）条件下。此外，我们还检测了血容量、肾功能、血浆电解质和蛋白质水平的变化，以及血浆醛固酮浓度的变化。侧脑室注射AM可增加血浆AVP水平，而AM核酶处理可降低刺激条件下的血浆AVP水平。在低血容量的挑战，AM核酶治疗导致增加损失的血浆容量相比，对照组动物。虽然总体血浆渗透压没有治疗组之间的差异，在低血容量，醛固酮水平显着较高，因此，血浆钾浓度较低的AM核酶治疗的大鼠比对照组。这些数据表明，脑源性AM是加压素分泌的生理调节剂，从而，流体稳态。
Central nervous system-derived adrenomedullin (AM) has been shown to be a physiological regulator of thirst. Administration of AM into the lateral ventricle of the brain attenuated water intake, whereas a decrease in endogenous AM, induced by an AM-specific ribozyme, led to exaggerated water intake. We hypothesized that central AM may control fluid homeostasis, in part by regulating plasma arginine vasopressin (AVP) levels. To test this hypothesis, AM or a ribozyme specific to AM was administered intracerebroventricularly, and alterations in plasma AVP concentrations were examined under basal and stimulated (hypovolemic) conditions. Additionally, we examined changes in blood volume, kidney function, and plasma electrolyte and protein levels, as well as changes in plasma aldosterone concentrations. Intracerebroventricular administration of AM increased plasma AVP levels, whereas AM ribozyme treatment led to decreased plasma AVP levels under stimulated conditions. During hypovolemic challenges, AM ribozyme treatment led to an increased loss of plasma volume compared with control animals. Although overall plasma osmolality did not differ between treatment groups during hypovolemia, aldosterone levels were significantly higher and, consequently, plasma potassium concentrations were lower in AM ribozyme-treated rats than in controls. These data suggest that brain-derived AM is a physiological regulator of vasopressin secretion and, thereby, fluid homeostasis.
纳洛酮诱导催产素和催乳素释放的解离。
影响因子：
4.1
作者：
Samson,WK;McDonald,JK;Lumpkin,MD
通讯作者：
Lumpkin,MD
心房钠尿因子抑制脱水和出血引起的加压素释放。
影响因子：
4.1
作者：
Samson,WK
通讯作者：
Samson,WK
肉芽肿中生长抑素受体 sst2A 的免疫组织化学定位。
影响因子：
5.5
作者：
tenBokum,AM;Hofland,LJ;deJong,G;Bouma,J;Melief,MJ;Kwekkeboom,DJ;Schonbrunn,A;Mooy,CM;Laman,JD;Lamberts,SW;vanHagen,PM
通讯作者：
vanHagen,PM