The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases.
The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases.
复制标题
DOI：
10.1002/art.30155
复制
发表时间：
2011-03
影响因子：
--
通讯作者：
Gabriel, Sherine E.
中科院分区：
文献类型：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
对类风湿性关节炎（RA）和其他风湿性疾病的个人风险的理解仍然很差，尽管其发病机制，治疗方法和临床影响的知识取得了进展，部分原因是发展这些疾病的个人终身风险是未知的。估计RA以及其他炎性自身免疫性风湿性疾病（包括系统性红斑狼疮、银屑病关节炎、风湿性多肌痛（PMR）、巨细胞动脉炎、强直性脊柱炎和干燥综合征）的终生风险，并提供终生发生炎性自身免疫性风湿性疾病风险的总体估计。使用从明尼苏达州奥姆斯特德县居民中风湿性疾病的基于人群的研究中获得的发病率和一般人群生命表中的死亡率，我们估计了风湿性疾病的性别特异性终身风险。美国成年人发生类风湿关节炎的终生风险为女性3.6%和男性1.7%，类风湿因子阳性的终生风险为女性2.4%和男性1.1%。第二种最常见的炎症性自身免疫性风湿病是PMR，女性终生风险为2.4%，男性为1.7%。炎症性自身免疫性风湿病的总体终生风险为女性8.4%和男性5.1%。每12名女性中就有1名，每20名男性中就有1名在其一生中会患上炎症性自身免疫性风湿病。这些结果可以作为有用的指导，在咨询患者关于他们的终身风险，这些条件，并有重要意义的疾病意识运动。
Understanding of the personal risks for rheumatoid arthritis (RA) and other rheumatic diseases remains poor, despite advances in knowledge of their pathogenesis, therapeutics, and clinical impact, in part because the personal lifetime risk of developing these diseases is unknown. To estimate the lifetime risk of RA, as well as other inflammatory autoimmune rheumatic diseases, including systemic lupus erythematosus, psoriatic arthritis, polymyalgia rheumatica (PMR), giant cell arteritis, ankylosing spondylitis, and Sjögren’s syndrome, and to provide an overall estimate of the risk for developing inflammatory autoimmune rheumatic disease over a lifetime. Using the incidence rates obtained from our population-based studies of rheumatic diseases among residents of Olmsted County, Minnesota, and mortality rates from life tables for the general population, we estimated sex-specific lifetime risk of rheumatic disease. The lifetime risk of RA developing in US adults is 3.6% for women and 1.7% for men, and the lifetime risk of rheumatoid factor positive RA is 2.4% for women and 1.1% for men. The second most common inflammatory autoimmune rheumatic disease is PMR with a lifetime risk of 2.4% for women and 1.7% among men. The overall lifetime risk of inflammatory autoimmune rheumatic disease was 8.4% for women and 5.1% for men. One in 12 women and 1 in 20 men will develop inflammatory autoimmune rheumatic disease during their lifetime. These results can serve as useful guides in counseling patients regarding their lifetime risk of these conditions and have important implications for disease awareness campaigns.
登录
查看更多内容
影响因子：
--
作者：
Myasoedova, Elena;Crowson, Cynthia S.;Kremers, Hilal Maradit;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
9.9
作者：
Seshadri, S;Wolf, PA;D'Agostino, RB
通讯作者：
D'Agostino, RB
影响因子：
--
作者：
Lawrence, Reva C.;Felson, David T.;Wolfe, Frederick
通讯作者：
Wolfe, Frederick
影响因子：
--
作者：
Doran, MF;Pond, GR;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
--
作者：
Hemminki, Kari;Li, Xinjun;Sundquist, Kristina
通讯作者：
Sundquist, Kristina