Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.
Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.
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喉鳞状细胞癌肿瘤微环境中的肿瘤浸润淋巴细胞：系统评价和荟萃分析。
DOI：
10.3390/biomedicines9050486
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发表时间：
2021-04-28
期刊：
影响因子：
4.7
通讯作者：
Ferlito A
中科院分区：
文献类型：
--
作者：
Rodrigo JP;Sánchez-Canteli M;López F;Wolf GT;Hernández-Prera JC;Williams MD;Willems SM;Franchi A;Coca-Pelaz A;Ferlito A
肿瘤微环境中肿瘤浸润淋巴细胞（TIL）的存在已被证明在各种癌症中具有预后价值。在这篇系统综述和荟萃分析中，我们研究了TIL在喉鳞癌（LSCC）中的预后价值。我们在PubMed上进行了系统的搜索，以研究TIL在LSCC中的预后价值。我们进行了一项荟萃分析，包括所有评估苏木精-伊红（HE）染色切片中CD8+和/或CD3+/CD4+ TIL计数与总生存期（OS）或无病生存期（DFS）之间关系的研究。合并荟萃分析显示，HE切片中基质TIL对OS （HR 0.57, 95% CI 0.36-0.91, p = 0.02）和DFS （HR 0.56, 95% CI 0.34-0.94, p = 0.03）具有良好的预后作用。高CD8+ TIL与延长的OS （HR 0.62, 95% CI 0.4-0.97, p = 0.04）和DFS （HR 0.73, 95% CI 0.34-0.94, p = 0.002）相关。高CD3+/CD4+ TIL可改善OS （HR 0.32, 95% CI 0.16-0.9, p = 0.03）和DFS （HR 0.23, 95% CI 0.10-0.53, p = 0.0005）。该荟萃分析证实了TIL在LSCC中的良好预后意义。高间质TIL在HE切片和肿瘤内和间质CD3+， CD4+和/或CD8+ TIL中评估可能预测更好的临床结果。
The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. A meta-analysis was performed including all studies assessing the association between TIL counts in hematoxylin-eosin (HE)-stained sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free survival (DFS). The pooled meta-analysis showed a favorable prognostic role for stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36–0.91, p = 0.02), and for DFS (HR 0.56, 95% CI 0.34–0.94, p = 0.03). High CD8+ TIL were associated with a prolonged OS (HR 0.62, 95% CI 0.4–0.97, p = 0.04) and DFS (HR 0.73, 95% CI 0.34–0.94, p = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% CI 0.16–0.9, p = 0.03) and DFS (HR 0.23, 95% CI 0.10–0.53, p = 0.0005). This meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, CD4+ and/or CD8+ TIL might predict a better clinical outcome.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
8.8
作者：
Balermpas, P;Michel, Y;Wagenblast, J;Seitz, O;Weiss, C;Rodel, F;Rodel, C;Fokas, E
通讯作者：
Fokas, E
影响因子：
11.5
作者：
Badoual, C;Hans, S;Tartour, E
通讯作者：
Tartour, E
影响因子：
2
作者：
Franz, Leonardo;Alessandrini, Lara;Marioni, Gino
通讯作者：
Marioni, Gino
影响因子：
2.1
作者：
Chatzopoulos, Kyriakos;Kotoula, Vassiliki;Fountzilas, Georgios
通讯作者：
Fountzilas, Georgios