Ultrasonic Tissue Characterization of the Carotid Artery in Chronic Renal Failure Patients
Ultrasonic Tissue Characterization of the Carotid Artery in Chronic Renal Failure Patients
复制标题
慢性肾衰竭患者颈动脉的超声组织特征
作者：
M. Rossi;A. Cupisti;G. Santoro;E. Morelli;M. Meola;G. Barsotti
颈动脉壁的超声反射率，通过综合后向散射（IBS）分析测量，最近在动脉粥样硬化性疾病患者中进行了评估，并被认为是预后指标。我们对30例慢性肾衰竭（CRF）患者（血清肌酐548±230µmol/l）进行保守治疗，无心血管并发症的临床证据，对其颈动脉壁进行b模式测量和IBS分析；14例为正常血压（NT）， 16例为治疗高血压（TH）。30名性别和年龄相匹配的健康受试者作为对照。CRF患者的IBS颈动脉指数明显高于对照组（31.7±3.5 vs 28.9±2.3 dB; p < 0.001），而TH和NT CRF患者之间无差异。IBS指数与血浆低密度脂蛋白胆固醇水平呈负相关（r = -0.46, p < 0.05）， TH - CRF组患者IBS指数与体重指数、舒张压呈负相关。尿毒症患者和对照组的颈动脉内膜-中膜厚度相似。该研究表明，CRF患者颈动脉超声反射率增加，与明显动脉粥样硬化损伤的存在无关，可能与CRF相关的血管重构有关。IBS分析是检测动脉壁结构早期变化的有用工具。然而，应该计划前瞻性研究来确定其在尿毒症患者中的预后重要性。
The ultrasonic reflectivity of the carotid wall, measured by means of integrated backscatter (IBS) analysis, has recently been evaluated in patients with atherosclerotic diseases and it was considered to be a prognostic marker. We performed B-mode measurement and IBS analysis of the carotid wall in 30 chronic renal failure (CRF) patients (serum creatinine 548 ± 230 µmol/l) on conservative treatment and free of clinical evidence of cardiovascular complications; 14 were normotensives (NT) and 16 were treated hypertensives (TH). Thirty sex- and age-matched healthy subjects served as controls. The IBS carotid index was significantly higher in CRF patients than in controls (31.7 ± 3.5 vs. 28.9 ± 2.3 dB; p < 0.001), and no difference was observed between TH and NT CRF patients. The IBS index was negatively correlated with low-density lipoprotein cholesterol plasma levels (r = –0.46, p < 0.05), and within the group of TH CRF patients the IBS index was also negatively correlated with the body mass index and diastolic blood pressure. The carotid intima-media thickness was similar between uremic patients and controls. This study demonstrates an increment in carotid ultrasonic reflectivity in CRF patients, independent of the presence of overt atherosclerotic damage, and probably related to vascular remodelling linked to CRF. IBS analysis can be a useful tool to detect early changes in arterial wall structure. However, prospective studies should be planned to define its prognostic importance in uremic patients.
影响因子：
158.5
作者：
Goodman, WG;Goldin, J;Salusky, IB
通讯作者：
Salusky, IB