Cross species review of the physiological role of D-serine in translationally relevant behaviors.
Cross species review of the physiological role of D-serine in translationally relevant behaviors.
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DOI：
10.1007/s00726-023-03338-6
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发表时间：
2023-11
期刊：
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
弥合神经和精神疾病临床前模型与其人类表现之间的差距对于了解其潜在机制、识别生物标志物和开发新的治疗方法是必要的。认知和社交障碍是多种神经精神和神经疾病的基础，通常与睡眠障碍合并症，这可能加剧不良后果。重要的是，许多症状在脊椎动物和无脊椎动物之间是保守的，尽管它们可能有细微的差异。因此，有必要确定不同物种之间这些行为的分子机制及其对人类的可翻译性。全基因组关联研究表明，谷氨酸能基因变异与精神分裂症、双相情感障碍和自闭症谱系障碍等精神疾病的风险和频率之间存在关联。例如，谷氨酸能神经传递的改变，如谷氨酸受体亚型n -甲基-d-天冬氨酸受体（NMDAR）功能低下，已被证明与精神分裂症的病理生理有关。此外，在创伤性脑损伤和阿尔茨海默病等神经系统疾病中，NMDARs的过度激活会导致突触损伤。除了谷氨酸结合外，NMDARs还需要协同激动剂d-丝氨酸或甘氨酸与GluN1亚基结合才能打开。d-丝氨酸是由l-丝氨酸通过神经元酶丝氨酸消旋酶（SRR）外消旋而成的，SRR和d-丝氨酸都富集于皮质边缘脑区。d-丝氨酸对认知和社会行为等复杂行为至关重要，其合成和释放的失调与许多病理状况有关。在这篇综述中，我们探讨了d-丝氨酸在跨物种不同模型中与多种精神和神经疾病翻译相关的行为中的作用。
Bridging the gap between preclinical models of neurological and psychiatric disorders with their human manifestations is necessary to understand their underlying mechanisms, identify biomarkers, and develop novel therapeutics. Cognitive and social impairments underlie multiple neuropsychiatric and neurological disorders and are often comorbid with sleep disturbances, which can exacerbate poor outcomes. Importantly, many symptoms are conserved between vertebrates and invertebrates, although they may have subtle differences. Therefore, it is essential to determine the molecular mechanisms underlying these behaviors across different species and their translatability to humans. Genome-wide association studies have indicated an association between glutamatergic gene variants and both the risk and frequency of psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. For example, changes in glutamatergic neurotransmission, such as glutamate receptor subtype N-methyl-d-aspartate receptor (NMDAR) hypofunction, have been shown to contribute to the pathophysiology of schizophrenia. Furthermore, in neurological disorders, such as traumatic brain injury and Alzheimer’s disease, hyperactivation of NMDARs leads to synaptic damage. In addition to glutamate binding, NMDARs require the binding of a co-agonist d-serine or glycine to the GluN1 subunit to open. d-serine, which is racemized from l-serine by the neuronal enzyme serine racemase (SRR), and both SRR and d-serine are enriched in cortico-limbic brain regions. d-serine is critical for complex behaviors, such as cognition and social behavior, where dysregulation of its synthesis and release has been implicated in many pathological conditions. In this review, we explore the role of d-serine in behaviors that are translationally relevant to multiple psychiatric and neurological disorders in different models across species.
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DOI：
10.1111/j.1601-183x.2010.00656.x
发表时间：
2011-03
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
DeVito LM;Balu DT;Kanter BR;Lykken C;Basu AC;Coyle JT;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
10.6
作者：
Balu DT;Presti KT;Huang CCY;Muszynski K;Radzishevsky I;Wolosker H;Guffanti G;Ressler KJ;Coyle JT
通讯作者：
Coyle JT
影响因子：
3.8
作者：
Bicks LK;Koike H;Akbarian S;Morishita H
通讯作者：
Morishita H
影响因子：
11
作者：
Basu, A. C.;Tsai, G. E.;Coyle, J. T.
通讯作者：
Coyle, J. T.
影响因子：
4
作者：
Benneyworth MA;Li Y;Basu AC;Bolshakov VY;Coyle JT
通讯作者：
Coyle JT