Current experimental perspectives on the clinical progression of alcoholic liver disease.
Current experimental perspectives on the clinical progression of alcoholic liver disease.
复制标题
酒精性肝病临床进展的当前实验观点。
DOI：
10.1111/j.1530-0277.2009.01015.x
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Dooley S
中科院分区：
文献类型：
--
作者：
Breitkopf K;Nagy LE;Beier JI;Mueller S;Weng H;Dooley S
慢性酒精滥用是全球发病和死亡的一个重要原因。慢性酒精中毒导致的肝脏损伤最初会使肝脏内脂质堆积，随着持续接触酒精，这种脂肪变性的状况可能首先发展到炎症阶段，进而引发纤维生成，最终导致肝硬化。虽然该疾病的早期阶段被认为是可逆的，但肝脏结构的肝硬化破坏超过一定限度会导致器官不可逆转的损伤，并且常常是癌症发生的基础。这篇综述将总结关于酒精性肝病（ALD）不同阶段潜在分子机制的现有知识。近期的观察结果使得ALD的新分子机制和介质得以确定。例如，纤溶酶原激活物抑制剂1被证明在脂肪变性中起核心作用，抗炎脂肪因子脂联素深刻地调节肝脏巨噬细胞功能，慢性酒精中毒会导致肝脏铁过度沉积，增加肝细胞癌发生的风险。
Chronic alcohol abuse is an important cause of morbidity and mortality throughout the world. Liver damage due to chronic alcohol intoxication initially leads to accumulation of lipids within the liver and with ongoing exposure this condition of steatosis may first progress to an inflamma-tory stage which leads the way for fibrogenesis and finally cirrhosis of the liver. While the earlier stages of the disease are considered reversible, cirrhotic destruction of the liver architecture beyond certain limits causes irreversible damage of the organ and often represents the basis for cancer development. This review will summarize current knowledge about the molecular mechanisms underlying the different stages of alcoholic liver disease (ALD). Recent observations have led to the identification of new molecular mechanisms and mediators of ALD. For example, plasminogen activator inhibitor 1 was shown to play a central role for steatosis, the anti-inflammatory adipokine, adiponectin profoundly regulates liver macrophage function and excessive hepatic deposition of iron is caused by chronic ethanol intoxication and increases the risk of hepatocellular carcinoma development.
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影响因子：
4.7
作者：
Frank, A;Seitz, HK;Nair, J
通讯作者：
Nair, J
DOI：
10.1111/j.1440-1746.2007.05277.x
发表时间：
2008-03-01
影响因子：
4.1
作者：
De Minicis, Samele;Brenner, David A.
通讯作者：
Brenner, David A.
影响因子：
--
作者：
Barck, KH;Lee, WP;Carano, RAD
通讯作者：
Carano, RAD
影响因子：
3.9
作者：
Anania, FA;Potter, JJ;Mezey, E
通讯作者：
Mezey, E
影响因子：
3.9
作者：
Albano, Emanuele
通讯作者：
Albano, Emanuele