Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System
Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous System
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人类中枢神经系统中脂质过氧化的区域特异性脆弱性
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
R. Pamplona
中科院分区：
文献类型：
--
作者：
A. Naudí;M. Jové;V. Ayala;O. Ramírez;R. Cabré;J. Prat;M. Portero;I. Ferrer;R. Pamplona
人类神经系统中大约 1000 亿个神经元负责协调极其广泛的运动、感觉、调节、行为和执行功能。这种多样化的功能输出是神经细胞，特别是神经元中发生的不同分子事件的产物。在形态学上，中枢神经系统 (CNS) 神经元的大小、树突的数量和复杂性、突触连接的数量、轴突的长度和建立突触连接的距离、轴突髓鞘化的程度以及其他细胞特征各不相同。神经元的多样性也通过在神经递质的基础上包含化学特异性而得到放大，神经递质用于化学传递或神经调节。神经元群体之间的巨大多样性强烈表明，尽管所有神经元的基因组中都包含相同的遗传密码，但每个神经元群体都有自己的基因表达谱。虽然神经元结构和功能的多样性已得到充分记录，但人们较少认识到神经元对衰老过程中或神经退行性疾病造成的压力和不利因素的不同反应。此外，为了增加已经异质的景观的复杂性，通常被描述为“支持矩阵”的非神经元群体最近被认为是中枢神经系统功能中活跃的、信息丰富的细胞对应物。
Around 100 billion neurons in the human nervous system orchestrate an exceptionally wide range of motor, sensory, regulatory, behavioural, and executive functions. Such diverse functional output is the product of different molecular events occurring in nervous cells and particularly, neurons. Morphologically, central nervous system (CNS) neurons differ in size, number and complexity of dendrites, number of synaptic connections, length of axons and distance across which synaptic connections are established, extent of axonal myelination, and other cellular characteristics. Neuronal diversity is also amplified by the inclusion of chemical specificity on the basis of the neurotransmitters, which they use for chemical transmission or neuromodulation. This great diversity among neuronal populations is a strong indication that although all neurons contain the same genetic code in their genome, each neuronal population has their own gene expression profile. While the diversity of neuronal structures and functions are well documented, what is less appreciated is the diverse response of neurons to stresses and adverse factors during aging or as a result of neurodegenerative diseases. Furthermore, to add complexity to an already heterogeneous landscape, non-neuronal populations, often described as a ‘supporting matrix’ are recently being recognized as active, information-rich, cellular counterpart in CNS function.
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影响因子：
4.7
作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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