Identification of a Rare EGFR T790I Mutation in Lung Adenocarcinoma Sensitive to Osimertinib.

Identification of a Rare EGFR T790I Mutation in Lung Adenocarcinoma Sensitive to Osimertinib.
复制标题

鉴定对奥希替尼敏感的肺腺癌中罕见的 EGFR T790I 突变

DOI:
10.3389/fonc.2021.727312
复制
发表时间:
2021
影响因子:
4.7
通讯作者:
Dong W
Dong W
中科院分区:
医学3区
文献类型:
--
作者:
Wang Y;Liu S;Feng A;Luo H;Hu J;Wang K;Dong W

文献摘要

参考文献

相似文献

估计肾小球滤过率(EGFR)敏感突变对于肺癌的靶向治疗策略极其重要。奥西莫替尼能有效抑制EGFR敏感突变的活性,包括T790M突变。然而,奥西美替尼对罕见的T790突变类型的有效性尚不清楚。在这里,我们报告了一例携带T790I突变的中国肺腺癌(LADC)患者,他从奥西美替尼治疗中获得了显著的好处。
Estimated glomerular filtration rate (EGFR)-sensitive mutations are extremely important for targeted treatment strategies in lung cancer. Osimertinib can effectively inhibit the activity of EGFR-sensitive mutations, including the T790M mutation. However, the efficiency of osimertinib for rare mutation types of T790 is unclear. Here, we report the case of a Chinese patient with lung adenocarcinoma (LADC) harboring a T790I mutation who achieved significant benefits from osimertinib treatment.
DOI: 10.1056/nejmoa1913662
发表时间: 2020-01-02
影响因子: 158.5
作者:
Ramalingam, S. S.;Vansteenkiste, J.;Nguyen, Nhung
通讯作者: Nguyen, Nhung
DOI: 10.1021/acs.jcim.9b00361
发表时间: 2019-06-01
影响因子: 5.6
作者:
Kannan, Srinivasaraghavan;Fox, Stephen J.;Verma, Chandra S.
通讯作者: Verma, Chandra S.
DOI: 10.1158/2159-8290.cd-14-0337
发表时间: 2014-09
期刊: Cancer discovery
影响因子: 28.2
作者:
Cross DA;Ashton SE;Ghiorghiu S;Eberlein C;Nebhan CA;Spitzler PJ;Orme JP;Finlay MR;Ward RA;Mellor MJ;Hughes G;Rahi A;Jacobs VN;Red Brewer M;Ichihara E;Sun J;Jin H;Ballard P;Al-Kadhimi K;Rowlinson R;Klinowska T;Richmond GH;Cantarini M;Kim DW;Ranson MR;Pao W
通讯作者: Pao W
DOI: 10.1038/nsmb.1486
发表时间: 2008-10
影响因子: 16.8
作者:
通讯作者: --
DOI: 10.1158/1078-0432.ccr-12-2246
发表时间: 2013-04-15
期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子: --
作者:
Yu HA;Arcila ME;Rekhtman N;Sima CS;Zakowski MF;Pao W;Kris MG;Miller VA;Ladanyi M;Riely GJ
通讯作者: Riely GJ