Relationship between glycosylated hemoglobin A1c and ocular circulation by laser speckle flowgraphy in patients with/without diabetes mellitus
Relationship between glycosylated hemoglobin A1c and ocular circulation by laser speckle flowgraphy in patients with/without diabetes mellitus
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激光散斑血流成像检测糖尿病/非糖尿病患者糖化血红蛋白 A1c 与眼循环的关系
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Y. Hori
中科院分区：
文献类型：
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作者：
Chieko Shiba;T. Shiba;Mao Takahashi;Tadashi Matsumoto;Y. Hori
目的探讨激光散斑血流成像（LSFG）显示的视神经头（ONH）和脉络膜血流动力学与糖尿病（DM）患者空腹血糖（FBS）和HbA1c水平是否存在显著相关性。方法对连续196例患者（男151例，女45例）进行分析。评估ONH和脉络膜的平均模糊率（MBR）、井喷评分（BOS）和井喷时间（BOT）的脉冲波形分析参数。我们使用多元回归分析来确定与FBS或HbA1c显著相关的LSFG参数的独立因素。我们评估了147例非糖尿病患者的LSFG参数FBS和HbA1c之间的关系。结果多元回归分析显示，红细胞压积和HbA1c是影响脉络膜MBR的独立因素。年龄、性别、脉压、心率、球折射和HbA1c被确定为影响ONH中BOS的独立因素。多元回归分析显示，年龄、身高、脉压、心率和HbA1c是影响脉络膜BOS的独立因素。Pearson相关分析显示，非糖尿病患者ONH和脉络膜中的BOT值与HbA1c显著相关。结论HbA1c即使在正常范围内，也会影响ONH和脉络膜的血流。LSFG可能是检测无症状眼循环异常的有效方法。
PurposeTo determine whether there are significant correlations between the hemodynamics of the optic nerve head (ONH) and choroid as shown by laser speckle flowgraphy (LSFG) and the fasting blood sugar (FBS) and HbA1c level in patients with/without diabetes mellitus (DM).MethodsWe analyzed 196 consecutive patients (151 men, 45 women). The pulse waveform analysis parameters of the mean blur rate (MBR), blowout score (BOS) and blowout time (BOT) in the ONH and choroid were evaluated. We used a multiple regression analysis to determine the independent factors for the LSFG parameters that are significantly correlated with FBS or HbA1c. We evaluated the relationship between the LSFG parameters FBS and HbA1c obtained from the 147 non-DM patients.ResultsThe multiple regression analysis revealed that hematocrit and HbA1c were factors contributing independently to the choroid MBR. The age, gender, pulse pressure, heart rate, spherical refraction and HbA1c were identified as factors contributing independently to the BOS in the ONH. The multiple regression analysis indicated that age, height, pulse pressure, heart rate and HbA1c were factors contributing independently to the BOS in the choroid. A Pearson’s correlation analysis showed that the BOT values in the ONH and choroid were significantly correlated with the HbA1c in the non-DM patients.ConclusionOur results confirmed that HbA1c, even within the normal range, affected the blood flow in the ONH and choroid. LSFG may be a useful method to detect abnormalities of asymptomatic ocular circulation.
DOI：
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发表时间：
1995-09
期刊：
The American journal of pathology
影响因子：
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作者：
D. Mcleod;D. Lefer;C. Merges;G. Lutty
通讯作者：
D. Mcleod;D. Lefer;C. Merges;G. Lutty