Retirement and Socioeconomic Differences in Diurnal Cortisol: Longitudinal Evidence From a Cohort of British Civil Servants.
Retirement and Socioeconomic Differences in Diurnal Cortisol: Longitudinal Evidence From a Cohort of British Civil Servants.
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DOI：
10.1093/geronb/gbx058
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发表时间：
2018-03-02
期刊：
影响因子：
--
通讯作者：
Kumari M
中科院分区：
文献类型：
--
作者：
Chandola T;Rouxel P;Marmot MG;Kumari M
老年过早和退休前后与健康方面社会经济不平等的扩大有关。很少有研究涉及与这种扩大有关的压力-生物因素。本研究考察了退休是否与更有利（更陡峭）的皮质醇日谱相关，以及职业等级之间这种关联的差异。伦敦白厅II公务员研究的第7（2002-2004）、第8（2006）和第9（2007-09）阶段的数据进行了分析。在第8阶段工作的1443名受访者（平均年龄59.9岁）和在第7和第9阶段收集的五个样本中测量的唾液皮质醇进行了分析。与那些继续工作的人相比，退休后的人的日斜率更大。与成绩最好的员工相比，成绩最差的员工每天的皮质醇斜率更平坦。特别是与高级退休人员相比，低级退休人员的日斜率更平坦。在退休前后，与压力相关的生物标志物的社会经济差异会增加，而不是减少。这些与不同职业群体的退休过渡相关的生物学差异可能部分解释了老年早期健康方面的社会不平等日益扩大的模式。
Early old age and the period around retirement are associated with a widening in socioeconomic inequalities in health. There are few studies that address the stress-biological factors related to this widening. This study examined whether retirement is associated with more advantageous (steeper) diurnal cortisol profiles, and differences in this association by occupational grade. Data from the 7th (2002–2004), 8th (2006), and 9th (2007–09) phases of the London-based Whitehall II civil servants study were analysed. Thousand hundred and forty three respondents who were employed at phase 8 (mean age 59.9 years) and who had salivary cortisol measured from five samples collected across the day at phases 7 and 9 were analysed. Retirement was associated with steeper diurnal slopes compared to those who remained in work. Employees in the lowest grades had flatter diurnal cortisol slopes compared to those in the highest grades. Low-grade retirees in particular had flatter diurnal slopes compared to high-grade retirees. Socioeconomic differences in a biomarker associated with stress increase, rather than decrease, around the retirement period. These biological differences associated with transitions into retirement for different occupational groups may partly explain the pattern of widening social inequalities in health in early old age.
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