Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study.
Is there an association between work stress and diurnal cortisol patterns? Findings from the Whitehall II study.
复制标题
DOI：
10.1371/journal.pone.0081020
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kumari M
中科院分区：
文献类型：
--
作者：
Liao J;Brunner EJ;Kumari M
关于下丘脑-垂体-肾上腺轴是否存在与工作压力相关的失调的证据尚不明确。这项研究在一个大规模的职业队列中评估了工作压力和皮质醇昼夜节律之间的关系，即白厅II研究。采用工作需求-控制（JDC）模型和努力-回报-不平衡（ERI）模型对工作压力进行了评估。在2002-2004年期间，他们在正常的一天内收集了六次唾液皮质醇样本。计算皮质醇觉醒反应（CAR）和皮质醇日下降（斜率）。在这个大型职业队列中（N = 2126，平均年龄57.1），仅在ERI模型中发现了皮质醇模式的适度差异，显示较低的奖励（β = - 0.001， p值= 0.04）和较高的ERI （β = 0.002， p值= 0.05）与皮质醇在一天中的平缓斜率有关。同时，在CAR和JDC模型上观察到适度的性别交互作用。我们得出结论，工作压力与皮质醇的关联是适度的，与ERI模型而不是JDC模型的关联明显。
The evidence on whether there is work stress related dysregulation of the hypothalamic-pituitary-adrenal axis is equivocal. This study assessed the relation between work stress and diurnal cortisol rhythm in a large-scale occupational cohort, the Whitehall II study. Work stress was assessed in two ways, using the job-demand-control (JDC) and the effort-reward-imbalance (ERI) models. Salivary cortisol samples were collected six times over a normal day in 2002–2004. The cortisol awakening response (CAR) and diurnal cortisol decline (slope) were calculated. In this large occupational cohort (N = 2,126, mean age 57.1), modest differences in cortisol patterns were found for ERI models only, showing lower reward (β = −0.001, P-value = 0.04) and higher ERI (β = 0.002, P-value = 0.05) were related to a flatter slope in cortisol across the day. Meanwhile, moderate gender interactions were observed regarding CAR and JDC model. We conclude that the associations of work stress with cortisol are modest, with associations apparent for ERI model rather than JDC model.
登录
查看更多内容
影响因子：
8.2
作者：
Chandola, Tarani;Heraclides, Alexandros;Kumari, Meena
通讯作者：
Kumari, Meena
影响因子：
2.6
作者：
Bellingrath, Silja;Weigl, Tobias;Kudielka, Brigitte M.
通讯作者：
Kudielka, Brigitte M.
影响因子：
3.8
作者：
Hanson, EKS;Maas, CJM;Godaert, GLR
通讯作者：
Godaert, GLR
影响因子：
105.7
作者：
Chandola, T;Brunner, E;Marmot, M
通讯作者：
Marmot, M
影响因子：
6.3
作者：
Fujiwara, K;Tsukishima, E;Kishi, R
通讯作者：
Kishi, R