mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines.
mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines.
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mirTrans：人类细胞系 microRNA 转录调控的资源
DOI：
10.1093/nar/gkx996
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发表时间：
2018-01-04
影响因子：
14.9
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Hua X;Tang R;Xu X;Wang Z;Xu Q;Chen L;Wingender E;Li J;Zhang C;Wang J
摘要microRNA（miRNAs）转录调控的细胞特异性信息对于精确理解不同组织和细胞类型中存在的各种生理和病理过程中的基因调控至关重要。该数据库mirTrans提供了关于miRNA的细胞特异性转录的全面信息，包括miRNA的转录起始位点（TSS）、转录因子（TF）对miRNA的调控和miRNA启动子序列。mirTrans还绘制了miRNA启动子内的实验性H3 K4 me 3和DHS（DNase-I超敏位点）标记以及转录区域内的表达序列标签（EST）。目前版本的数据库涵盖了35259个TSS和54个人类细胞系中1513个miRNA的230多万个TF-miRNA调控。这些细胞系跨越大部分生物系统，包括循环系统、消化系统和神经系统。提供了基因内miRNAs和基因间miRNAs的信息。特别地，通过文献整理来评估miRNA TSS和TF-miRNA调节的质量。23447条TSS记录和2148条TF-miRNA法规得到了文献整理的特殊实验的支持。EST覆盖率还用于评估miRNA TSS的准确性。mirTrans界面设计友好，便于下载（http：mcube.nju.edu.cn/jwang/lab/soft/mirtrans/或http：//120.27.239.192/mirtrans/）。
Abstract The cell-specific information of transcriptional regulation on microRNAs (miRNAs) is crucial to the precise understanding of gene regulations in various physiological and pathological processes existed in different tissues and cell types. The database, mirTrans, provides comprehensive information about cell-specific transcription of miRNAs including the transcriptional start sites (TSSs) of miRNAs, transcription factor (TF) to miRNA regulations and miRNA promoter sequences. mirTrans also maps the experimental H3K4me3 and DHS (DNase-I hypersensitive site) marks within miRNA promoters and expressed sequence tags (ESTs) within transcribed regions. The current version of database covers 35 259 TSSs and over 2.3 million TF-miRNA regulations for 1513 miRNAs in a total of 54 human cell lines. These cell lines span most of the biological systems, including circulatory system, digestive system and nervous system. Information for both the intragenic miRNAs and intergenic miRNAs is offered. Particularly, the quality of miRNA TSSs and TF-miRNA regulations is evaluated by literature curation. 23 447 TSS records and 2148 TF-miRNA regulations are supported by special experiments as a result of literature curation. EST coverage is also used to evaluate the accuracy of miRNA TSSs. Interface of mirTrans is friendly designed and convenient to make downloads (http://mcube.nju.edu.cn/jwang/lab/soft/mirtrans/ or http://120.27.239.192/mirtrans/).
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影响因子：
9.5
作者：
Bhattacharyya, Malay;Das, Manali;Bandyopadhyay, Sanghamitra
通讯作者：
Bandyopadhyay, Sanghamitra
影响因子：
7
作者：
Siepel, A;Bejerano, G;Haussler, D
通讯作者：
Haussler, D
影响因子：
7
作者：
Pollard, Katherine S.;Hubisz, Melissa J.;Siepel, Adam
通讯作者：
Siepel, Adam
识别细胞特异性 microRNA 转录起始位点
影响因子：
5.8
作者：
Hua, Xu;Chen, Luxiao;Wingender, Edgar
通讯作者：
Wingender, Edgar
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK