Repairing quite swimmingly: advances in regenerative medicine using zebrafish.
Repairing quite swimmingly: advances in regenerative medicine using zebrafish.
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DOI：
10.1242/dmm.016352
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发表时间：
2014-07
影响因子：
4.3
通讯作者：
North TE
中科院分区：
文献类型：
--
作者：
Goessling W;North TE
再生医学有望减轻器官功能障碍、长期损伤和创伤造成的发病率和死亡率。虽然一些疾病的再生方法已经非常成功，但一些器官要么不能很好地再生，要么目前没有治疗方法来利用其内在的再生潜力。在这篇综述中，我们描述了人类疾病和斑马鱼组织修复的建模，通过使用经典的正向遗传筛选发现致病基因，并通过化学遗传筛选方法调节临床相关的表型。此外，我们还概述了与哺乳动物组织相比在斑马鱼中再生良好的器官系统，以及从鱼类到哺乳动物的再生潜力保守的器官，从而能够在临床前疾病相关模型中发现药物。我们从自己的工作中提供了两个例子，其中斑马鱼研究结果的临床转化要么迫在眉睫，要么已经被证明是成功的。在多个器官中的有希望的结果表明，未来将从斑马鱼研究中进一步深入了解再生机制和新的临床相关治疗方法。
Regenerative medicine has the promise to alleviate morbidity and mortality caused by organ dysfunction, longstanding injury and trauma. Although regenerative approaches for a few diseases have been highly successful, some organs either do not regenerate well or have no current treatment approach to harness their intrinsic regenerative potential. In this Review, we describe the modeling of human disease and tissue repair in zebrafish, through the discovery of disease-causing genes using classical forward-genetic screens and by modulating clinically relevant phenotypes through chemical genetic screening approaches. Furthermore, we present an overview of those organ systems that regenerate well in zebrafish in contrast to mammalian tissue, as well as those organs in which the regenerative potential is conserved from fish to mammals, enabling drug discovery in preclinical disease-relevant models. We provide two examples from our own work in which the clinical translation of zebrafish findings is either imminent or has already proven successful. The promising results in multiple organs suggest that further insight into regenerative mechanisms and novel clinically relevant therapeutic approaches will emerge from zebrafish research in the future.
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DOI：
10.1016/j.ddmod.2012.02.001
发表时间：
2013
期刊：
Drug discovery today. Disease models
影响因子：
--
作者：
Esterberg, Robert;Coffin, Allison B;Ou, Henry;Simon, Julian A;Raible, David W;Rubel, Edwin W
通讯作者：
Rubel, Edwin W
影响因子：
64.5
作者：
Goessling W;North TE;Loewer S;Lord AM;Lee S;Stoick-Cooper CL;Weidinger G;Puder M;Daley GQ;Moon RT;Zon LI
通讯作者：
Zon LI
影响因子：
29
作者：
Donovan, A;Lima, CA;Andrews, NC
通讯作者：
Andrews, NC
影响因子：
20.3
作者：
de Jong, Jill L. O.;Burns, Caroline Erter;Zon, Leonard I.
通讯作者：
Zon, Leonard I.
影响因子：
5.3
作者：
Dovey, Michael;Patton, E. Elizabeth;Zon, Leonard I.
通讯作者：
Zon, Leonard I.