The Living Heart Project: A robust and integrative simulator for human heart function.
The Living Heart Project: A robust and integrative simulator for human heart function.
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DOI：
10.1016/j.euromechsol.2014.04.001
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发表时间：
2014-11
影响因子：
4.1
通讯作者：
Kuhl, Ellen
中科院分区：
文献类型：
--
作者：
Baillargeon, Brian;Rebelo, Nuno;Fox, David D.;Taylor, Robert L.;Kuhl, Ellen
心脏不仅是我们最重要的器官，也是我们最复杂的器官：由电场和机械场的相互作用精确控制，它由四个腔室和四个瓣膜组成，它们共同作用以调节其填充，喷射和整体泵功能。虽然存在许多计算模型来研究其单个腔室的电或机械响应，但整个心脏的综合机电响应仍然知之甚少。在这里，我们提出了一个概念验证的模拟器，从计算机地形图和磁共振图像创建的四腔人类心脏模型。我们说明了控制方程的激发-收缩耦合和离散他们使用一个单一的，统一的有限元环境。为了说明我们模型的基本特征，我们将整个心动周期中人类心脏的电位和机械变形可视化。为了将我们的模拟与心脏功能的常见指标进行比较，我们提取了压力-容积关系，并表明它与临床观察结果吻合良好。我们的原型模型使我们能够探索和理解关键特征、物理和技术，以创建一个完整的、可预测的活体人类心脏模型。最终，我们的模拟器将为探索临床参数的景观提供机会，并指导心脏疾病的器械设计和治疗计划，如主动脉瓣、肺动脉瓣、三尖瓣或二尖瓣的狭窄、反流或脱垂。
The heart is not only our most vital, but also our most complex organ: Precisely controlled by the interplay of electrical and mechanical fields, it consists of four chambers and four valves, which act in concert to regulate its filling, ejection, and overall pump function. While numerous computational models exist to study either the electrical or the mechanical response of its individual chambers, the integrative electro-mechanical response of the whole heart remains poorly understood. Here we present a proof-of-concept simulator for a four-chamber human heart model created from computer topography and magnetic resonance images. We illustrate the governing equations of excitation-contraction coupling and discretize them using a single, unified finite element environment. To illustrate the basic features of our model, we visualize the electrical potential and the mechanical deformation across the human heart throughout its cardiac cycle. To compare our simulation against common metrics of cardiac function, we extract the pressure-volume relationship and show that it agrees well with clinical observations. Our prototype model allows us to explore and understand the key features, physics, and technologies to create an integrative, predictive model of the living human heart. Ultimately, our simulator will open opportunities to probe landscapes of clinical parameters, and guide device design and treatment planning in cardiac diseases such as stenosis, regurgitation, or prolapse of the aortic, pulmonary, tricuspid, or mitral valve.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
DOI：
10.1080/10255842.2012.729582
发表时间：
2014
影响因子：
1.6
作者：
Hurtado DE;Kuhl E
通讯作者：
Kuhl E
影响因子：
2.4
作者：
De Hart, J;Peters, GWM;Baaijens, FPT
通讯作者：
Baaijens, FPT
DOI：
10.1002/cnm.2573
发表时间：
2013-11-01
影响因子：
2.1
作者：
Krishnamoorthi, Shankarjee;Sarkar, Mainak;Klug, William S.
通讯作者：
Klug, William S.
DOI：
10.1016/j.cma.2014.02.002
发表时间：
2014-05-01
影响因子：
7.2
作者：
Hurtado, Daniel E.;Henao, Duvan
通讯作者：
Henao, Duvan