Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma‐derived cell lines
Molecular cytogenetic characterization of del(7q) in two uterine leiomyoma‐derived cell lines
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两种子宫肌瘤来源细胞系 del(7q) 的分子细胞遗传学特征
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
H. van den Berghe
中科院分区：
文献类型：
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作者：
R. Vanni;S. Marras;E. Schoenmakers;P. Cin;B. Kazmierczak;G. Senger;J. Bullerdiek;W. V. D. Van de Ven;H. van den Berghe
子宫肌瘤细胞遗传学表现出至少六个染色体异常亚组。最大的亚组的特征是 7 号染色体长臂的缺失。很少有分子和荧光原位杂交数据可用于更好地定义病变。在这里，我们报告了两条 del(7q) 染色体的部分分子细胞遗传学表征结果，这些染色体源自两个带有 del(7)(q22q32) 的子宫肌瘤建立的细胞系。通过使用大量有序的 7q 标记，我们能够识别最近端和最远端的保守标记，这些标记描绘了缺失的大小，并允许对可能与疾病发病机制相关的基因的性质和功能采取更有针对性的方法。基因染色体。癌症 18：155–161，1997 年。© 1997 Wiley-Liss, Inc.
Uterine leiomyoma cytogenetically exhibits at least six chromosomally abnormal subgroups. The largest subgroup is characterized by deletions of the long arm of chromosome 7. Few molecular and fluorescence in situ hybridization data are available that have aimed at a better definition of the lesion. Here, we report the results of a partial molecular cytogenetic characterization of two del(7q) chromosomes that were derived from cell lines established from two uterine leiomyomas with del(7)(q22q32). By using a large series of ordered 7q markers, we were able to identify the most proximal and the most distal conserved markers, which delineate the size of the deletion and which allow for a more targeted approach to the nature and function of genes that are possibly relevant for the pathogenesis of the disorder. Genes Chromosom. Cancer 18:155–161, 1997. © 1997 Wiley‐Liss, Inc.
子宫肌瘤中的克隆染色体重排。
影响因子：
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作者：
Gibas,Z;Griffin,CA;Emanuel,BS
通讯作者：
Emanuel,BS
人类 7 号染色体的物理、遗传和细胞遗传学图谱的整合：酵母人工染色体克隆的 117 个映射遗传标记的分离和分析。
影响因子：
3.5
作者：
Green,ED;Idol,JR;Mohr-Tidwell,RM;Braden,VV;Peluso,DC;Fulton,RS;Massa,HF;Magness,CL;Wilson,AM;Kimura,J
通讯作者：
Kimura,J