Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.
Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects.
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DOI：
10.1371/journal.pone.0076115
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wakefield LM
中科院分区：
文献类型：
--
作者：
Luger D;Yang YA;Raviv A;Weinberg D;Banerjee S;Lee MJ;Trepel J;Yang L;Wakefield LM
The role of myeloid derived suppressor cells (MDSCs) in promoting tumorigenesis is well-established, and significant effort is being made to further characterize surface markers on MDSCs both for better diagnosis and as potential targets for therapy. Here we show that the B cell receptor adaptor molecule CD79a is unexpectedly expressed on immature bone marrow myeloid cells, and is upregulated on MDSCs generated in multiple different mouse models of metastatic but not non-metastatic cancer. CD79a on MDSCs is upregulated and activated in response to soluble factors secreted by tumor cells. Activation of CD79a on mouse MDSCs, by crosslinking with a specific antibody, maintained their immature phenotype (CD11b+Gr1+), enhanced their migration, increased their suppressive effect on T cell proliferation, and increased secretion of pro-tumorigenic cytokines such as IL-6 and CCL22. Furthermore, crosslinking CD79a on myeloid cells activated signaling through Syk, BLNK, ERK and STAT3 phosphorylation. In vivo, CD79+ myeloid cells showed enhanced ability to promote primary tumor growth and metastasis. Finally we demonstrate that CD79a is upregulated on circulating myeloid cells from lung cancer patients, and that CD79a+ myeloid cells infiltrate human breast tumors. We propose that CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy.
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影响因子：
4.3
作者：
Day CP;Carter J;Bonomi C;Esposito D;Crise B;Ortiz-Conde B;Hollingshead M;Merlino G
通讯作者：
Merlino G
影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
影响因子：
11.2
作者：
Faget, Julien;Biota, Cathy;Menetrier-Caux, Christine
通讯作者：
Menetrier-Caux, Christine
DOI：
10.1126/stke.3772007re2
发表时间：
2007-03-13
期刊：
Science's STKE : signal transduction knowledge environment
影响因子：
--
作者：
Abram, Clare L;Lowell, Clifford A
通讯作者：
Lowell, Clifford A
影响因子：
4.8
作者：
Benlagha, K;Guglielmi, P;Lassoued, K
通讯作者：
Lassoued, K