New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction.

New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction.
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DOI:
10.1016/j.ucl.2017.04.014
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发表时间:
2017-08
期刊:
The Urologic clinics of North America
影响因子:
--
通讯作者:
Yoshimura N
Yoshimura N
中科院分区:
其他
文献类型:
--
作者:
Miyazato M;Kadekawa K;Kitta T;Wada N;Shimizu N;de Groat WC;Birder LA;Kanai AJ;Saito S;Yoshimura N

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下尿路的主要功能是储存和排出。排尿反射途径受脊髓球脊髓反射途径以及参与自主排尿控制的高级脑中枢的调节。排尿对许多损伤很敏感,导致各种类型的功能障碍。动物研究表明,下尿路功能障碍部分取决于神经通路的可塑性。反射可塑性与离子通道、受体和众多介质的变化有关。动物模型可能有助于了解神经源性损伤后下尿路反射通路的可塑性和导致病理情况的机制。
The lower urinary tract’s main functions are storage and elimination. The micturition reflex pathway is modulated by the spinobulbospinal reflex pathway as well as higher brain centers involved in the voluntary micturition control. Micturition is sensitive to numerous injuries, resulting in various types of dysfunction. Animal studies indicate that lower urinary tract dysfunction partly depends on plasticity of the neural pathways. Reflex plasticity is associated with changes in ion channels, receptors, and numerous mediators. Animal models may aid in understanding the mechanisms leading to pathologic conditions and the plasticity in reflex pathways to the lower urinary tract after neurogenic lesions.
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