Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy.
Investigation of dose reduction in cardiac perfusion SPECT via optimization and choice of the image reconstruction strategy.
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DOI：
10.1007/s12350-017-0920-1
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发表时间：
2018-12
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我们研究了在何种程度上可以减少管理剂量（活动）水平，而不牺牲诊断准确性的SPECT心肌灌注成像（MPI）的三种重建策略。我们使用一组混合研究（来自190名受试者）优化了三种重建策略的参数，用于在一系列模拟给药剂量水平上进行灌注缺陷检测，这些研究由修改后的临床SPECT-MPI数据组成，以包含逼真的模拟病变。我们考虑的优化策略是滤波反投影（FBP），没有校正退化，有序子集期望最大化（OS-EM）与衰减校正（AC），散射校正（SC），分辨率校正（RC），和OS-EM与散射和分辨率校正。使用定量灌注SPECT（QPS）软件包计算的总灌注缺损（TPD）评分评价每项研究。我们根据每个剂量水平和重建策略的TPD评分进行了受试者工作特征（ROC）研究。对于EBP，在标准剂量的100%、50%、25%和12.5%下达到的ROC曲线下面积（AUC）的最佳值分别为0.75、0.74、0.72和0.70，相比之下，OS-EM与AC-SC-RC的最佳值分别为0.81、0.79、0.76和0.74，OS-EM与AC-SC-RC的最佳值分别为0.78、0.77、0.74、0.78和0.79。0.72对于OS-EM和SC-RC。我们的研究结果表明，通过OS-EM与AC-SC-RC重建的研究可能平均减少至原始给药剂量的25%，而不会导致诊断准确性（AUC）降低至低于FBP。
We investigated the extent to which the administered dose (activity) level can be reduced without sacrificing diagnostic accuracy for three reconstruction strategies for SPECT-myocardial perfusion imaging (MPI). We optimized the parameters of the three reconstruction strategies for perfusion-defect detection over a range of simulated administered dose levels using a set of hybrid studies (derived from 190 subjects) consisting of clinical SPECT-MPI data modified to contain realistic simulated lesions. The optimized strategies we considered are filtered backprojection (FBP) with no correction for degradations, ordered-subsets expectation-maximization (OS-EM) with attenuation correction (AC), scatter correction (SC), and resolution correction (RC), and OS-EM with scatter and resolution correction only. Each study was evaluated using a total perfusion deficit (TPD) score computed by the Quantitative Perfusion SPECT (QPS) software package. We conducted a receiver operating characteristics (ROC) study based on the TPD scores for each dose level and reconstruction strategy. For EBP, the achieved optimum values of the area under the ROC curve (AUC) at 100%, 50%, 25% and 12.5% of standard dose were 0.75, 0.74, 0.72 and 0.70, respectively, compared to 0.81, 0.79, 0.76 and 0.74 for OS-EM with AC-SC-RC and 0.78, 0.77, 0.74, 0.72 for OS-EM with SC-RC. Our results suggest that studies reconstructed by OS-EM with AC-SC-RC could possibly be reduced, on average, to 25% of the originally administered dose without causing diagnostic accuracy (AUC) to decrease below that of FBP.
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影响因子：
2.4
作者：
Borges-Neto, Salvador;Pagnanelli, Robert A.;Coleman, Ralph Edward
通讯作者：
Coleman, Ralph Edward
影响因子：
2.4
作者：
Slomka, PJ;Nishina, H;Germano, G
通讯作者：
Germano, G
影响因子：
1.8
作者：
Narayanan, MV;King, MA;Gifford, HC
通讯作者：
Gifford, HC
影响因子：
39.3
作者：
Einstein AJ;Pascual TN;Mercuri M;Karthikeyan G;Vitola JV;Mahmarian JJ;Better N;Bouyoucef SE;Hee-Seung Bom H;Lele V;Magboo VP;Alexánderson E;Allam AH;Al-Mallah MH;Flotats A;Jerome S;Kaufmann PA;Luxenburg O;Shaw LJ;Underwood SR;Rehani MM;Kashyap R;Paez D;Dondi M;INCAPS Investigators Group
通讯作者：
INCAPS Investigators Group
影响因子：
2.4
作者：
DePuey, E. Gordon;Bommireddipalli, Srinivas;Srour, Yossi
通讯作者：
Srour, Yossi