Percutaneous conchotome muscle biopsy. A useful diagnostic and assessment tool.
Percutaneous conchotome muscle biopsy. A useful diagnostic and assessment tool.
复制标题
经皮壳状肌活检。
DOI：
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复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
I. Lundberg
中科院分区：
文献类型：
--
作者：
C. Dorph;I. Nennesmo;I. Lundberg
目的
在风湿病门诊中，评价经皮耳板刀肌肉活检技术用于临床和研究目的的诊断率、性能简单性和安全性。
方法
在1996年和1997年期间，由风湿病学家在门诊诊所采取的活检组织病理学和临床诊断进行了评价。
结果
共对122例患者进行了149次活检。医生很容易就学会了这个方法。样本的大小和质量足以进行诊断。由于不同的诊断怀疑，总共进行了106次活检：24次多发性肌炎（PM）或皮肌炎（DM）; 43次PM、DM或血管炎以及另一种风湿性疾病; 19次系统性血管炎; 20次肌痛。21例患者符合明确或可能PM/DM的标准，其中18例活检阳性。13例患者接受血管炎作为临床诊断，3例活检阳性。没有肌痛患者有炎症变化的活检。为评估疾病活动性而进行的43次重新活检中有15次有活动性炎症的迹象。在48%的患者中，活检结果后免疫抑制治疗发生变化。发生4例并发症; 1例为严重筋膜下血肿。
结论
经皮锥切肌活检技术提供了一个很好的大小的样本，允许诊断评估，并在肌炎患者的产率高。这是一个简单的程序，易于学习和执行，并发症发生率低，病人的不适最小。该方法可优选用作诊断工具，并进行重复的活组织检查，以评估用于临床和研究目的的给定疗法的效果。
OBJECTIVE
To evaluate the diagnostic yield, performance simplicity, and safety of the percutaneous conchotome muscle biopsy technique for clinical and research purposes in an outpatient rheumatology clinic.
METHODS
Biopsies taken by rheumatologists in an outpatient clinic during 1996 and 1997 were evaluated for histopathological and clinical diagnoses.
RESULTS
A total of 149 biopsies were performed on 122 patients. Physicians learned the method easily. Samples were of adequate size and quality to allow for diagnostics. In total 106 biopsies were taken due to different diagnostic suspicions: 24 polymyositis (PM) or dermatomyositis (DM); 43 PM, DM, or vasculitis in addition to another rheumatic condition; 19 systemic vasculitis; and 20 myalgias. Criteria for definite or probable PM/DM were fulfilled in 21 patients, 18 with positive biopsies. Thirteen patients received vasculitis as clinical diagnosis, 3 with positive biopsies. No patient with myalgia had a biopsy with inflammatory changes. Fifteen of 43 rebiopsies performed to assess disease activity had signs of active inflammation. In 48% there were changes in immunosuppressive therapy after biopsy results. Four complications occurred; one was a serious subfascial hematoma.
CONCLUSION
The percutaneous conchotome muscle biopsy technique gives a good size sample that allows for diagnostic evaluation and has a high yield in patients with myositis. It is a simple procedure, easy to learn and to perform, with a low complication rate and minimum discomfort for the patient. The method can preferably be used as a diagnostic tool and to perform repeated biopsies to assess the effect of a given therapy for both clinical and research purposes.
炎症性肌病：诊断和治疗中的问题。
DOI：
10.1002/art.1790100308
发表时间：
1997
期刊：
Arthritis care and research : the official journal of the Arthritis Health Professions Association.
影响因子：
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作者：
Olsen,NJ;Park,JH
通讯作者：
Park,JH
肌肉针活检在大学风湿病学实践中的实用性。
DOI：
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发表时间：
1994
期刊：
The Journal of rheumatology
影响因子：
--
作者：
O'Rourke,KS;Blaivas,M;Ike,RW
通讯作者：
Ike,RW