Long-term outcomes in kidney transplant recipients with end-stage kidney disease due to anti-glomerular basement membrane disease.
Long-term outcomes in kidney transplant recipients with end-stage kidney disease due to anti-glomerular basement membrane disease.
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DOI：
10.1111/ctr.14179
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发表时间：
2021-03
影响因子：
2.1
通讯作者：
Panzer SE
中科院分区：
文献类型：
--
作者：
Singh T;Kharadjian TB;Astor BC;Panzer SE
抗肾小球基底膜（GBM）疾病导致快速进行性肾小球肾炎和终末期肾病（ESKD）。在美国，由于抗GBM疾病导致ESKD患者的移植后结局研究缺乏。为了更好地描述有抗GBM疾病史的移植受者的结局，我们在美国的一个中心研究了抗GBM疾病受者与伊加肾病受者的患者生存率和移植物生存率。我们分析了1994年至2015年期间在我们中心接受肾移植的ESKD受者的患者生存率、移植物生存率、疾病复发率和恶性肿瘤发生率，这些受者因活检证实的抗GBM疾病而接受肾移植。1994年至2015年，26例经活检证实的抗GBM疾病患者和314例IgAN患者接受了肾移植。抗GBM疾病的移植物丢失发生率为6.2/100人-年，与IgAN相似（4.08/100人-年，p = 0.09）。抗GBM的患者死亡率为0.03/100人-年，与IgAN相似（0.02/100人-年，p = 0.12）。26例抗GBM患者中有1例发生疾病复发。26例患者中有4例（15%）发生恶性肿瘤，最常见的是皮肤癌。抗GBM所致ESKD患者的长期移植物和患者存活率与肾移植后IgAN相似。
Anti-glomerular basement membrane (GBM) disease causes rapidly progressive glomerulonephritis and end-stage kidney disease (ESKD). Studies of post-transplant outcomes in patients with ESKD due to anti-GBM disease in the United States are lacking. To better characterize outcomes of transplant recipients with a history of anti-GBM disease, we examined patient survival and graft survival among recipients with anti-GBM disease compared with IgA nephropathy at a single center in the United States. We analyzed patient survival, graft survival, disease recurrence, and malignancy rates for kidney transplant recipients with ESKD due to biopsy-proven anti-GBM disease who underwent kidney transplantation at our center between 1994 and 2015. 26 patients with biopsy-proven anti-GBM disease and 314 patients with IgAN underwent kidney transplantation from 1994 to 2015. The incidence of graft loss was 6.2 per 100 person-years for anti-GBM disease, which was similar to IgAN (4.08 per 100 person-years, p = .09). Patient mortality for anti-GBM was 0.03 per 100 person-years, similar to IgAN (0.02 per 100 person-years, p = .12). Disease recurrence occurred in one of the 26 anti-GBM patients. Four out of 26 patients (15%) developed malignancy, most commonly skin cancer. Long-term graft and patient survival for patients with ESKD due to anti-GBM was similar to IgAN after kidney transplantation.
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影响因子：
4.1
作者：
Jorgenson, Margaret R.;Descourouez, Jillian L.;Panzer, Sarah E.
通讯作者：
Panzer, Sarah E.
影响因子：
158.5
作者：
Briganti, EM;Russ, GR;Chadban, SJ
通讯作者：
Chadban, SJ
影响因子：
13.2
作者：
Borza, DB;Chedid, MF;Fervenza, FC
通讯作者：
Fervenza, FC
影响因子：
8.8
作者：
Kasiske, BL;Snyder, JJ;Wang, CC
通讯作者：
Wang, CC
影响因子：
6.1
作者：
Khandelwal, M;McCormick, BB;Cattran, DC
通讯作者：
Cattran, DC