Association of Epstein-Barr Virus with Hodgkin’s Disease

Association of Epstein-Barr Virus with Hodgkin’s Disease
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EB 病毒与霍奇金病的关联

DOI:
10.1007/978-1-4899-1100-1_20
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发表时间:
1995
期刊:
The Kitakanto Medical Journal
影响因子:
--
通讯作者:
A. Gloghini
A. Gloghini
中科院分区:
--
文献类型:
--
作者:
M. Boiocchi;R. Dolcetti;V. Re;A. Carbone;A. Gloghini

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霍奇金病(HD)的本质及其特征性细胞Reed-Sternberg(RS)细胞的起源至今仍不清楚,尽管关于这种疾病的文献丰富。近年来,HD是一种恶性淋巴瘤的概念已被病理学家、临床医生和从事该疾病研究的医学研究人员广泛接受。然而,迄今为止,关于肿瘤增殖的标准参数,如克隆性、染色体异常和可移植性,所积累的证据仍有争议。关于HD作为肿瘤性淋巴组织增生性疾病的另一个谜是在表征该疾病的多态性组织病理学背景中发生的推定肿瘤细胞(RS细胞及其变体)的百分比极低。相比之下,公认的肿瘤性淋巴组织增生性疾病,所谓的非霍奇金淋巴瘤(NHL),通常表现出单态性组织学模式,并主要由单克隆或更罕见的寡克隆细胞群组成。
The nature of Hodgkin’s disease (HD) and the origin of its characteristic cells, the Reed-Sternberg (RS) cells, are still obscure in spite of the abundant literature on this disorder. In recent years, the concept that HD is a malignant lymphoma has become widely accepted among pathologists, clinicians, and medical researchers working on this disease. However, the evidence accumulated so far with regard to the standard parameters defining neoplastic proliferation, such as clonality, chromosomal abnormality, and transplantability, is still controversial. A further enigma concerning HD as a neoplastic lymphoproliferative disease is the extremely low percentage of putative neoplastic cells (RS cells and their variants) occurring in the polymorphic histopathological setting that characterizes the disease. In contrast, well-recognized neoplastic lymphoproliferative diseases, the so-called non-Hodgkin’s lymphomas (NHLs), usually show monomorphic histological patterns and are constituted predominantly of monoclonal or, more rarely, oligoclonal cell populations.
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