Hybrid multicomponent hydrogels for tissue engineering.

Hybrid multicomponent hydrogels for tissue engineering.
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DOI:
10.1002/mabi.200800284
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发表时间:
2009-02-11
影响因子:
4.6
通讯作者:
Kiick, Kristi L.
Kiick, Kristi L.
中科院分区:
工程技术3区
文献类型:
--
作者:
Jia, Xinqiao;Kiick, Kristi L.

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人工ECM不仅可以模拟天然ECM的杂化特性,还可以提供可调的材料特性和增强的生物功能,是组织工程应用的热门候选材料。本文综述了通过将模块化和非均相构建块集成到定义良好的多功能水凝胶复合材料中来开发多组分杂化水凝胶的最新进展。各个构建单元在化学上、形态上和功能上都是不同的,杂交可以在分子水平或微观水平上进行。设计的模块化性质,再加上混合体系的潜在协同效应,导致了具有坚固结构和明确功能的新型水凝胶基质。
Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrating modular and heterogeneous building blocks into well-defined, multifunctional hydrogel composites. The individual building blocks can be chemically, morphologically, and functionally diverse, and the hybridization can occur at molecular level or microscopic scale. The modular nature of the designs, combined with the potential synergistic effects of the hybrid systems, has resulted in novel hydrogel matrices with robust structure and defined functions.
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