Ring around the Ro-sie: RNA-mediated alterations of PNPase activity.
Ring around the Ro-sie: RNA-mediated alterations of PNPase activity.
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DOI:
10.1016/j.cell.2013.03.005
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发表时间:
2013-03-28
期刊:
影响因子:
64.5
通讯作者:
Wilusz J
中科院分区:
文献类型:
--
作者:
Geiss BJ;Wilusz J
Chen et al. demonstrate a new way by which non-coding RNAs tailor the function of multi-component complexes. They show that a non-coding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold, and perhaps a gate for entry of the RNA substrate.
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