COVID-19 in multiple sclerosis and neuromyelitis optica spectrum disorder patients in Latin America: COVID-19 in MS and NMOSD patients in LATAM.
COVID-19 in multiple sclerosis and neuromyelitis optica spectrum disorder patients in Latin America: COVID-19 in MS and NMOSD patients in LATAM.
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DOI：
10.1016/j.msard.2021.102886
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发表时间：
2021-06
影响因子：
4
通讯作者：
Rojas JI
中科院分区：
文献类型：
--
作者：
Alonso R;Silva B;Garcea O;Diaz PEC;Dos Passos GR;Navarro DAR;Valle LAG;Salinas LCR;Negrotto L;Luetic G;Tkachuk VA;Míguez J;de Bedoya FHD;Goiry LG;Sánchez NER;Burgos M;Steinberg J;Balbuena ME;Alvarez PM;López PA;Ysrraelit MC;León RA;Cohen AB;Gracia F;Molina O;Casas M;Deri NH;Pappolla A;Patrucco L;Cristiano E;Tavolini D;Nadur D;Granda AMT;Weiser R;Cassará FP;Sinay V;Rodríguez CC;Lazaro LG;Menichini ML;Piedrabuena R;Escobar GO;Carrá A;Chertcoff A;Pujols BS;Vrech C;Tarulla A;Carvajal R;Mainella C;Becker J;Peeters LM;Walton C;Serena MA;Nuñez S;Rojas JI
没有关于COVID-19在拉丁美洲多发性硬化症（MS）和视神经肌萎缩症谱系障碍（NMOSD）患者中的数据。本研究的目的是描述RELACOEM中纳入的患者的临床特征和结局，RELACOEM是一项针对感染COVID-19的MS和NMOSD患者的LATAM登记研究。RELACOEM是一项纵向的、严格观察的登记研究，对象是在拉丁美洲患有COVID-19和登革热的MS和NMOSD患者。登记研究的入选标准为：（1）基于鼻咽拭子COVID-19聚合酶链反应（PCR）检测阳性结果的生物学确诊COVID-19诊断;或（2）COVID-19流行区的COVID-19典型症状（咳嗽、发热和虚弱三联征）。对人口统计学和临床变量进行描述性统计。随后对该队列进行MS和NMOSD分层，并进行单变量和多变量logistic回归分析，以确定与住院/重症监护室（ICU）入院相关的变量。来自15个国家的145名患者和51名治疗医生被纳入登记研究。共有129例（89%）为MS患者，16例（11%）为NMOSD患者。81.4%的患者已确诊COVID-19，18.6%为疑似病例。23名（15.8%）患者住院，9名（6.2%）患者需要ICU，5名（3.4%）患者因COVID-19死亡。在MS患者中，年龄较大（OR 1.17，95%CI 1.05 - 1.25）和疾病持续时间（OR 1.39，95%CI 1.14-1.69）与住院/ICU相关。在NMOSD患者中，年龄较大（54.3 vs. 36岁，p=<0.001）、EDSS增加（5.5 vs. 2.9，p=0.0012）和疾病持续时间（18.5 vs. 10.3年，p=0.001）与住院/ICU显著相关。我们发现在MS患者中，年龄和病程与住院和ICU入院要求相关，而在NMOSD中，年龄、病程和EDSS相关。
There is no data regarding COVID-19 in Multiple Sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) patients in Latin America. The objective of this study was to describe the clinical characteristics and outcomes of patients included in RELACOEM, a LATAM registry of MS and NMOSD patients infected with COVID-19. RELACOEM is a longitudinal, strictly observational registry of MS and NMOSD patients who suffer COVID-19 and Dengue in LATAM. Inclusion criteria to the registry were either: (1) a biologically confirmed COVID-19 diagnosis based on a positive result of a COVID-19 polymerase chain reaction (PCR) test on a nasopharyngeal swab; or (2) COVID-19–typical symptoms (triad of cough, fever, and asthenia) in an epidemic zone of COVID-19. Descriptive statistics were performed on demographic and clinical variables. The cohort was later stratified for MS and NMOSD and univariate and multivariate logistic regression analysis was performed to identify variables associated with hospitalizations/intensive critical units (ICU) admission. 145 patients were included in the registry from 15 countries and 51 treating physicians. A total of 129 (89%) were MS patients and 16 (11%) NMOSD. 81.4% patients had confirmed COVID-19 and 18.6% were suspected cases. 23 (15.8%) patients were hospitalized, 9 (6.2%) required ICU and 5 (3.4 %) died due to COVID-19. In MS patients, greater age (OR 1.17, 95% CI 1.05 – 1.25) and disease duration (OR 1.39, 95%CI 1.14-1.69) were associated with hospitalization/ICU. In NMOSD patients, a greater age (54.3 vs. 36 years, p=<0.001), increased EDSS (5.5 vs 2.9, p=0.0012) and disease duration (18.5 vs. 10.3 years, p=0.001) were significantly associated with hospitalization/ICU. we found that in MS patients, age and disease duration was associated with hospitalization and ICU admission requirement, while age, disease duration and EDSS was associated in NMOSD.
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影响因子：
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影响因子：
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作者：
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