Evaluation of COVID-19 infection in patients with Neuromyelitis optica spectrum disorder (NMOSD): A report from Iran.
Evaluation of COVID-19 infection in patients with Neuromyelitis optica spectrum disorder (NMOSD): A report from Iran.
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DOI：
10.1016/j.msard.2020.102245
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发表时间：
2020-09
影响因子：
4
通讯作者：
Naser Moghadasi A
中科院分区：
文献类型：
--
作者：
Sahraian MA;Azimi A;Navardi S;Rezaeimanesh N;Naser Moghadasi A
自2019年12月在中国武汉首次发现以来，COVID-19在全球范围内迅速传播，导致大量人员死亡和感染（Wang et al., 2020）。正常人中COVID-19的发病率从0.35%到13.3%不等（Signorelli et al., 2020）。有人警告说，患有基础疾病或服用免疫抑制药物的人可能更容易患上这种疾病或患有其并发症（Gavin et al., 2020）。由于使用免疫抑制药物来控制疾病，NMOSD患者更容易发生不同类型的感染（Sahraian et al., 2017; Damato et al., 2016）。因此，确定这些患者发生COVID-19的机会并提供必要的解决方案至关重要。在这项研究中，我们调查了NMOSD患者中COVID-19的流行情况，这些患者转诊到新浪医院的NMOSD诊所，这是一个接收来自伊朗各地患者的转诊中心。新浪医院NMOSD队列门诊共有149例患者。伊朗新冠肺炎疫情爆发后，于2020年5月2日至5月9日通过电话联系所有患者，询问其感染情况或可能出现的症状。在149名患者中，有130人接听了电话。其中女性112例，男性18例。平均年龄37.55±11.57岁，病程7.95±4.71年。最常用的药物是利妥昔单抗（72.3%）（表1）。5例（3.8%）感染冠状病毒（表2）。所有5例患者均接受利妥昔单抗治疗。服用利妥昔单抗的患者中COVID-19的患病率为5.1%，服用其他药物的患者中患病率为0%。三名患者为女性，两名患者为男性。患者平均年龄37.80±17.72岁，病程7.20±3.27年。感染患者的平均年龄与其余NMOSD人群的平均年龄无统计学差异。的
Since its inception in December 2019 in Wuhan, China, COVID-19 has spread rapidly around the world, killing and infecting a large number of people (Wang et al., 2020). The incidence of COVID-19 in normal people varies from 0.35% to 13.3%(Signorelli et al., 2020). It has been warned that people with an underlying diseases or taking immunosuppressive drugs may be more likely to develop the disease or suffer from its complications (Gavin et al., 2020). Patients with neuromyelitis optica spectrum disorder (NMOSD) are more prone to different types of infections due to use of immunosuppressive drugs to control the disease (Sahraian et al., 2017; Damato et al., 2016). Therefore, it is crucial to determine the chance of developing COVID-19 in these patients and provide the necessary solutions. In this study, we investigated the prevalence of COVID-19 among patients with NMOSD, who referred to NMOSD Clinic at Sina Hospital, a referral center receiving patients from all over Iran. There are 149 patients in NMOSD Cohort Clinic of Sina Hospital. After the outbreak of Coronavirus in Iran, all these patients were contacted by phone from May 2 to May 9, 2020, and were asked about their infection with the Coronavirus or probable symptoms. Out of 149 patients, 130 answered the phone. Of these 130 patients, 112 were females and 18 were males. The mean age was 37.55±11.57 years and their disease duration was 7.95±4.71 years. The most commonly used drug (72.3%) was rituximab (Table 1). Five patients (3.8%) were infected with Coronavirus (Table 2). All five patients were treated with rituximab. The prevalence of COVID-19 was 5.1% in patients taking rituximab and 0% in patients taking other drugs.Three patients were women and two patients were men. The mean age of these patients was 37.80±17.72 years and the disease duration was 7.20±3.27 years. There was not statistical difference between the mean age of infected patients and the rest of NMOSD population. The
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DOI：
10.23750/abm.v91i3-s.9511
发表时间：
2020-04-10
期刊：
Acta bio-medica : Atenei Parmensis
影响因子：
--
作者：
Signorelli C;Scognamiglio T;Odone A
通讯作者：
Odone A
影响因子：
29
作者：
Damato, Valentina;Evoli, Amelia;Iorio, Raffaele
通讯作者：
Iorio, Raffaele
影响因子：
8.8
作者：
Nikpouraghdam, Mohamad;Farahani, Alireza Jalali;Bagheri, Mahdi
通讯作者：
Bagheri, Mahdi
影响因子：
29.4
作者：
Cheung, Ka Shing;Hung, Ivan F. N.;Leung, Wai K.
通讯作者：
Leung, Wai K.