Breast cancer in very young women-a multicenter 10-year experience.
Breast cancer in very young women-a multicenter 10-year experience.
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DOI：
10.1016/j.esmoop.2020.100029
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发表时间：
2021-03
期刊：
影响因子：
7.3
通讯作者：
Braga S
中科院分区：
文献类型：
--
作者：
Eiriz IF;Vaz Batista M;Cruz Tomás T;Neves MT;Guerra-Pereira N;Braga S
乳腺癌（BC）是欧洲成年年轻女性中最常见的癌症。虽然罕见，但它是该年龄组死亡的主要原因之一。本研究的目的是描述一组年轻女性的肿瘤分期、生物学、治疗和生存情况。我们对2008年至2017年诊断为BC的35岁以下女性进行了多中心回顾性分析。共纳入了来自5个葡萄牙中心的207例患者，其中172例符合分析条件。使用IBM SPPSS统计分析数据。诊断时的中位年龄为31岁。51%的肿瘤为激素受体（HR）阳性/人表皮生长因子受体2（HER 2）阴性，20%为HR阳性/HER 2阳性，8%为HR阴性/HER 2阳性，20%为三阴性BC。22%的患者被诊断为I期，26%为II期，45%为III期，6%为新发转移性癌症。39%的患者接受了新辅助化疗。平均随访时间为64.9个月，整个队列和转移性患者的5年总生存率分别为86.5%和26%。在我们的研究中，我们发现与其他年龄<35岁的人群相似的人群特征。据我们所知，这是非常年轻女性中最大的群体之一。年轻女性的BC是一个重要的问题，需要进一步的研究来为患者提供更好的护理和生存。我们提出了一个大型队列的妇女<35岁时，与其他系列相比，我们发现相似的生存率。侵袭性亚型（HER 2和三阴性）在这个年龄组中比一般乳腺癌更普遍。该队列中有61%的人的BRCA状态未知。这对年轻女性来说是一个令人关切的重要问题。仅68%的HR阳性患者进行了卵巢功能抑制。我们发现，与我们的转移性乳腺癌系列相比，我们人群中的脑转移增加了四倍。
Breast cancer (BC) is the most prevalent cancer in adult young women in Europe. Although rare, it is one of the leading causes of death in this age group. The aim of this study is to characterize a cohort of young women regarding tumor stage, biology, treatment and survival. We present a multicenter retrospective analysis of women <35 years of age, diagnosed with BC between 2008 and 2017. A total of 207 patients from five Portuguese centers were included, from whom 172 were eligible for analysis. Data were analyzed using IBM SPPSS statistics. Median age at diagnosis was 31 years. Fifty-one percent of tumors were hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 20% HR-positive/HER2-positive, 8% HR-negative/HER2-positive and 20% triple-negative BC. Twenty-two percent of patients were diagnosed in stage I, 26% stage II, 45% stage III and 6% had de novo metastatic cancer. Thirty-nine percent of patients were treated with neoadjuvant chemotherapy. Mean follow-up time was 64.9 months and overall survival at 5 years, of the entire cohort and metastatic patients, was 86.5% and 26%, respectively. In our study we found similar population characteristics to other cohorts <35 years of age. To our knowledge, this is one of the largest cohorts in very young women. BC in young women is an important issue and further studies are needed to provide better care and survivorship to patients. We present a large cohort of women <35 years of age when compared with other series and we found similar survival rates. Aggressive subtypes (HER2 and triple-negative) are more prevalent in this age group than in breast cancer in general. Sixty-one percent of this cohort has unknown BRCA status. This is a concerning and important issue for young women. Ovarian function suppression was carried out in only 68% of HR-positive patients. We found a fourfold increase in brain metastasis in our population when compared with our series of metastatic breast cancer.
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影响因子：
3.8
作者：
Elkum N;Dermime S;Ajarim D;Al-Zahrani A;Alsayed A;Tulbah A;Al Malik O;Alshabanah M;Ezzat A;Al-Tweigeri T
通讯作者：
Al-Tweigeri T
DOI：
10.1016/s0140-6736(17)33326-3
发表时间：
2018-03-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Allemani C;Matsuda T;Di Carlo V;Harewood R;Matz M;Nikšić M;Bonaventure A;Valkov M;Johnson CJ;Estève J;Ogunbiyi OJ;Azevedo E Silva G;Chen WQ;Eser S;Engholm G;Stiller CA;Monnereau A;Woods RR;Visser O;Lim GH;Aitken J;Weir HK;Coleman MP;CONCORD Working Group
通讯作者：
CONCORD Working Group
DOI：
10.11604/pamj.2014.19.35.2849
发表时间：
2014
期刊：
The Pan African medical journal
影响因子：
--
作者：
Makanjuola D;Alkushi A;Alzaid M;Abukhair O;Al Tahan F;Alhadab A
通讯作者：
Alhadab A
影响因子：
8.8
作者：
Li, CI;Uribe, DJ;Daling, JR
通讯作者：
Daling, JR
影响因子：
3.6
作者：
Braga, Sofia;Miranda, Ana;Moreira, Antonio
通讯作者：
Moreira, Antonio