The effect of morphology upon electrophysiological responses of retinal ganglion cells: simulation results.
The effect of morphology upon electrophysiological responses of retinal ganglion cells: simulation results.
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DOI：
10.1007/s10827-013-0463-7
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发表时间：
2014-04
影响因子：
1.2
通讯作者：
Grayden, David B.
中科院分区：
文献类型：
--
作者：
Maturana, Matias I.;Kameneva, Tatiana;Burkitt, Anthony N.;Meffin, Hamish;Grayden, David B.
关键词：
视网膜神经节细胞（RGC）在形态和内在电生理学方面表现出差异。本研究的目的是表征解释 RGC 开和关行为的离子电流，并探讨是否所有形态类型的 RGC 都表现出电生理数据中描述的现象。我们将之前的 ON 和 OFF RGC 的单室细胞模型扩展到生物物理上更真实的多室细胞模型，并研究细胞形态对内在电生理特性的影响。使用霍奇金-赫胥黎型形式主义描述膜动力学。来自分离的完整小鼠视网膜的已发表的膜片钳数据的一个子集用于约束模型，另一个子集用于验证模型。在不同形态的神经元区室中用不同密度的离子电流模拟了 200 个形态不同的 ON 和 OFF RGC。我们的模型预测 ON 和 OFF 细胞之间的差异可以通过 OFF 细胞中存在低电压激活钙电流而 ON 细胞中不存在低压激活钙电流来解释。我们的研究通过模拟表明，特定形态类型的 RGC 能够表现出最近实验中描述的全部现象。不同细胞输出的比较表明，最能描述最近实验结果的 RGC 形态是体细胞与总表面积之比较大的形态。
Retinal ganglion cells (RGCs) display differences in their morphology and intrinsic electrophysiology. The goal of this study is to characterize the ionic currents that explain the behavior of ON and OFF RGCs and to explore if all morphological types of RGCs exhibit the phenomena described in electrophysiological data. We extend our previous single compartment cell models of ON and OFF RGCs to more biophysically realistic multicompartment cell models and investigate the effect of cell morphology on intrinsic electrophysiological properties. The membrane dynamics are described using the Hodgkin - Huxley type formalism. A subset of published patch-clamp data from isolated intact mouse retina is used to constrain the model and another subset is used to validate the model. Two hundred morphologically distinct ON and OFF RGCs are simulated with various densities of ionic currents in different morphological neuron compartments. Our model predicts that the differences between ON and OFF cells are explained by the presence of the low voltage activated calcium current in OFF cells and absence of such in ON cells. Our study shows through simulation that particular morphological types of RGCs are capable of exhibiting the full range of phenomena described in recent experiments. Comparisons of outputs from different cells indicate that the RGC morphologies that best describe recent experimental results are ones that have a larger ratio of soma to total surface area.
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影响因子：
2.5
作者：
Fohlmeister, JF;Miller, RF
通讯作者：
Miller, RF
影响因子：
2.9
作者：
Han, Y;Jacoby, RA;Wu, SM
通讯作者：
Wu, SM
影响因子：
1.2
作者：
Kameneva, Tatiana;Meffin, Hamish;Burkitt, Anthony N.
通讯作者：
Burkitt, Anthony N.
DOI：
10.1109/tnsre.2006.870488
发表时间：
2006-03-01
影响因子：
4.9
作者：
Schiefer, MA;Grill, WM
通讯作者：
Grill, WM
DOI：
10.1523/jneurosci.5694-09.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Margolis DJ;Gartland AJ;Euler T;Detwiler PB
通讯作者：
Detwiler PB