The Functions and Mechanisms of Action of Insulators in the Genomes of Higher Eukaryotes.
The Functions and Mechanisms of Action of Insulators in the Genomes of Higher Eukaryotes.
复制标题
高等真核生物基因组中绝缘子的功能和作用机制。
DOI：
10.32607/actanaturae.11144
复制
发表时间：
2020-10
期刊：
影响因子：
2
通讯作者：
Golovnin AK
中科院分区：
文献类型：
--
作者：
Melnikova LS;Georgiev PG;Golovnin AK
染色质区域之间的远程相互作用的机制和染色体结构形成的原则目前正在广泛的审查。被称为绝缘子的一类特殊的调节元件被认为参与调节增强子和启动子之间的特异性长程相互作用。本文综述了果蝇和哺乳动物的绝缘子，并简要描述了负责其功能活性的蛋白质。最初认为绝缘子的主要性质是阻断增强子和形成独立的转录结构域。我们目前的实验数据证明，绝缘体形成的染色质环在增强子阻断中只起辅助作用。本文还讨论了拓扑相关结构域的形成机制及其在染色体结构形成和基因转录调控中的作用。
The mechanisms underlying long-range interactions between chromatin regions and the principles of chromosomal architecture formation are currently under extensive scrutiny. A special class of regulatory elements known as insulators is believed to be involved in the regulation of specific long-range interactions between enhancers and promoters. This review focuses on the insulators of Drosophila and mammals, and it also briefly characterizes the proteins responsible for their functional activity. It was initially believed that the main properties of insulators are blocking of enhancers and the formation of independent transcription domains. We present experimental data proving that the chromatin loops formed by insulators play only an auxiliary role in enhancer blocking. The review also discusses the mechanisms involved in the formation of topologically associating domains and their role in the formation of the chromosomal architecture and regulation of gene transcription.
果蝇的外染色体东蛋白可以与聚染色体相关并调节基因表达。
影响因子：
3.7
作者：
Wasser, Martin;Chia, William
通讯作者：
Chia, William