Suppression of smooth pursuit eye movements induced by electrical stimulation of the monkey frontal eye field.
Suppression of smooth pursuit eye movements induced by electrical stimulation of the monkey frontal eye field.
复制标题
抑制猴子额眼区电刺激引起的平滑追踪眼球运动。
DOI：
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发表时间：
2011
影响因子：
2.5
通讯作者：
Y. Shinoda
中科院分区：
文献类型：
--
作者：
Y. Izawa;Hisao Suzuki;Y. Shinoda
本研究旨在研究电刺激训练猴的额叶眼场(FEF)对平滑追踪眼动的抑制特性。在被测试的刺激点，我们首先确定了产生电诱发眼跳(ESCs)的阈值。然后，我们考察了在低于诱发ESCs的阈值的强度下，刺激对平滑追逐的抑制作用。我们观察到，FEF刺激在追逐开始时和在亚阈值强度下维持追逐时，都导致了追逐的明显减速。即使在追逐过程中没有追赶眼跳的情况下，追逐也会被抑制，这表明压抑影响了追逐本身。我们绘制了与刺激对追踪的抑制效应相关的FEF区域。在FEF的一个大范围内，观察到了对自我的、但不是对抗性的追求的抑制效应。相反，我们在FEF的局部区域观察到了自发性和对抗性追踪的双边抑制。这一区域与我们之前已经证明刺激抑制双侧眼跳的产生以及在注视过程中放电的注视神经元集中在一起的区域相吻合。在这些结果的基础上，我们比较了追踪的FEF抑制和眼跳的几个生理特性，然后讨论了FEF在抑制追踪和眼跳中的作用，特别是在维持视觉注视方面的作用。
This study was performed to characterize the properties of the suppression of smooth pursuit eye movement induced by electrical stimulation of the frontal eye field (FEF) in trained monkeys. At the stimulation sites tested, we first determined the threshold for generating electrically evoked saccades (Esacs). We then examined the suppressive effects of stimulation on smooth pursuit at intensities that were below the threshold for eliciting Esacs. We observed that FEF stimulation induced a clear deceleration of pursuit at pursuit initiation and also during the maintenance of pursuit at subthreshold intensities. The suppression of pursuit occurred even in the absence of catch-up saccades during pursuit, indicating that suppression influenced pursuit per se. We mapped the FEF area that was associated with the suppressive effect of stimulation on pursuit. In a wide area in the FEF, suppressive effects were observed for ipsiversive, but not contraversive, pursuit. In contrast, we observed the bilateral suppression of both ipsiversive and contraversive pursuit in a localized area in the FEF. This area coincided with the area in which we have previously shown that stimulation suppressed the generation of saccades in bilateral directions and also where fixation neurons that discharged during fixation were concentrated. On the basis of these results, we compared the FEF suppression of pursuit with that of saccades with regard to several physiological properties and then discussed the role of the FEF in the suppression of both pursuit and saccades, and particularly in the maintenance of visual fixation.
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影响因子：
2.5
作者：
FUCHS, AF;ROBINSON, FR;STRAUBE, A
通讯作者：
STRAUBE, A
通过微刺激猴子弓形额叶追踪区域增强追踪眼运动的多个组成部分。
影响因子：
2.5
作者：
Tanaka,Masaki;Lisberger,StephenG
通讯作者：
Lisberger,StephenG
影响因子：
2.5
作者：
BRUCE, CJ;GOLDBERG, ME;STANTON, GB
通讯作者：
STANTON, GB
影响因子：
2.5
作者：
SEGRAVES, MA
通讯作者：
SEGRAVES, MA
猴子弓形额叶皮层在平滑追踪眼球运动中的作用。
影响因子：
2.5
作者：
Tanaka,Masaki;Lisberger,StephenG
通讯作者：
Lisberger,StephenG