A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION
A MATHEMATICAL SIMULATION OF THE INFLAMMATORY RESPONSE TO ANTHRAX INFECTION
复制标题
炭疽感染炎症反应的数学模拟
DOI：
10.1097/shk.0b013e318067dcfe
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发表时间：
2008
期刊：
影响因子：
3.1
通讯作者：
Y. Vodovotz
中科院分区：
文献类型：
--
作者：
Rukmini Kumar;C. Chow;J. Bartels;G. Clermont;Y. Vodovotz
炭疽杆菌（炭疽）可引发急性炎症反应，导致多系统器官衰竭和死亡。先前，我们开发了革兰氏阴性感染后急性炎症的数学模型，该模型与文献数据定性匹配。我们修改了该模型中入侵细菌的特性，使其具有炭疽杆菌的特异性，并模拟了宿主对炭疽感染的反应。我们模拟了在不同基因人群中针对炭疽的治疗策略，包括：(1)在不同时间点开始的抗生素治疗，(2)抗保护性抗原疫苗，以及(3)抗生素和疫苗的组合。与小鼠研究一致，我们的模拟表明，抗生素只有在炭疽感染过程的早期使用才能提高生存率。疫苗接种可导致形成针对保护性抗原的抗体，具有抗炎作用，有利于避免休克和提高生存率。然而，单独针对保护性抗原的抗体预计不能普遍预防炭疽感染。相反，我们的模拟表明，最佳策略是同时需要接种疫苗和使用抗生素。
Bacillus anthracis (anthrax) can trigger an acute inflammatory response that results in multisystem organ failure and death. Previously, we developed a mathematical model of acute inflammation after gram-negative infection that had been matched qualitatively to literature data. We modified the properties of the invading bacteria in that model to those specific to B. anthracis and simulated the host response to anthrax infection. We simulated treatment strategies against anthrax in a genetically diverse population including the following: (1) antibiotic treatment initiated at various time points, (2) antiprotective antigen vaccine, and (3) a combination of antibiotics and vaccine. In agreement with studies in mice, our simulations showed that antibiotics only improve survival if administered early in the course of anthrax infection. Vaccination that leads to the formation of antibodies to protective antigen is anti-inflammatory and beneficial in averting shock and improving survival. However, antibodies to protective antigen alone are predicted not to be universally protective against anthrax infection. Rather, our simulations suggest that an optimal strategy would require both vaccination and antibiotic administration.
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DOI：
10.1073/pnas.90.21.10198
发表时间：
1993-11-01
影响因子：
11.1
作者：
HANNA, PC;ACOSTA, D;COLLIER, RJ
通讯作者：
COLLIER, RJ
影响因子：
6
作者：
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通讯作者：
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DOI：
10.1172/jci16204
发表时间：
2002
期刊：
The Journal of clinical investigation
影响因子：
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作者：
Leppla,StephenH;Robbins,JohnB;Schneerson,Rachel;Shiloach,Joseph
通讯作者：
Shiloach,Joseph
影响因子：
2
作者：
Day, Judy;Rubin, Jonathan;Clermont, Gilles
通讯作者：
Clermont, Gilles
影响因子：
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作者：
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通讯作者：
P. Hanna